82-98) In this study, pulmonologists' underestimation of the sensitivity of sputum cytology, even for large central lesions
with a high probability of malignancy, may have contributed to their avoidance of this test.
Malignant peripheral nerve sheath tumors can occur almost anywhere, including the retroperitoneum, but a more peripheral location on the extremities is more common in the solitary (non-von Recklinghausen disease) form, whereas central lesions
on the trunk or head and neck predominate in neurofibromatosis.
Its more recent phylogenetic appearance could be the origin of a higher sensitivity of the abductor neurons to central lesions
and explain bilateral central abductor paralysis (or Gerhardt's syndrome).