cephalosporin


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cephalosporin

(sĕf'əlōspôr`ĭn), any of a group of more than 20 antibioticsantibiotic,
any of a variety of substances, usually obtained from microorganisms, that inhibit the growth of or destroy certain other microorganisms. Types of Antibiotics
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 derived from species of fungi of the genus Cephalosporium and closely related chemically to penicillinpenicillin,
any of a group of chemically similar substances obtained from molds of the genus Penicillium that were the first antibiotic agents to be used successfully in the treatment of bacterial infections in humans.
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. Cephalosporins, e.g., cefaclor (Ceclor), act against both gram-positive and gram-negative bacteria (see Gram's stainGram's stain,
laboratory staining technique that distinguishes between two groups of bacteria by the identification of differences in the structure of their cell walls. The Gram stain, named after its developer, Danish bacteriologist Christian Gram, has become an important tool
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) by inhibiting bacterial cell wall synthesis. They are widely used to treat gonorrhea, meningitis, and staphylococcal and streptococcal infections in patients who cannot use penicillin. Overuse of cephalosporins has led to increased bacterial resistance to the drugs (see drug resistancedrug resistance,
condition in which infecting bacteria can resist the destructive effects of drugs such as antibiotics and sulfa drugs. Drug resistance has become a serious public health problem, since many disease-causing bacteria are no longer susceptible to previously
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.)

cephalosporin

[‚sef·ə·lə′spȯr·ən]
(microbiology)
Any of a group of antibiotics produced by strains of the imperfect fungus Cephalosporium.
References in periodicals archive ?
TheAVMA is evaluating the prohibition of cephalosporins for preventive uses and will submit a response to the FDA during the comment period.
Estimation of overall effect size was only possible for reduction in CDAD, where the evidence suggested that restriction of clindamycin or third-generation cephalosporins resulted in an immediate reduction in prevalence by 15 cases per quarter, with an additional sustained reduction by 3 cases per quarter.
As a second-generation cephalosporin, Cefotetan is administered prior to surgery to help prevent surgical prophylaxis and secondary infection following certain abdominal and gynecological procedures such as colorectal surgery, vaginal or abdominal hysterectomies and cesarean sections.
using cephalosporin drugs in cattle, swine, chickens or turkeys that are not approved for use in that species (e.
The Company's anti-drug-resistance antibiotic, which combines a 3rd generation cephalosporin and a beta-lactamase inhibitor, is expected to be indicated for a wide variety of infections throughout the body, including: upper and lower respiratory tract infections (especially for pneumonia and bronchitis), ear and nose infections, bacterial Septicemia, meningitis, skin and skin structure infections, bone and joint infections, abdominal infections (peritonitis, cholecystitis, etc.
On October 23, the importer was informed of the laboratory's findings and the increased risk associated with salmonella isolates simultaneously resistant to quinolones and cephalosporins.
Ceftaroline is poised to be the only anti-MRSA cephalosporin on the market for community-acquired pneumonia between 2010 and 2015," said Decision Resources Therapeutic Area Director Danielle Drayton, Ph.
ZINFORO was designed to be different from previously approved cephalosporins and has a novel mode of action which results in bactericidal activity and broad coverage against common causative pathogens, such as Staphylococcus aureus, including MRSA, and Streptococci in cSSTI and Streptococcus pneumoniae and methicillin-susceptible Staphylococcus aureus (MSSA) in CAP.
CXA-101 is a potent, intravenously administered, anti-pseudomonal cephalosporin currently in Phase 2 study for the treatment of complicated urinary tract infections.
In contrast to the broad ST distribution of sensitive and intermediate penicillin-resistant strains, high-level penicillin and cephalosporin resistance was restricted to 4 STs (37, 67, 384, and the novel 1753).
Under an independent development program, Forest Laboratories will combine NXL104 in a treatment regimen with Forest's ceftaroline, a novel, bactericidal injectable broad spectrum cephalosporin being developed as a therapeutic agent for the treatment of gram-positive pathogens including methicillin resistant staphylococcus aureus (MRSA), and multi-drug resistant streptococcus pneumoniae (MDRSP), as well as common gram-negative organisms.
For 30 years, it has been supplying active ingredients, oral and injectable Penicillin and Cephalosporin Pharmaceutical Bulk, to Pharmaceutical Companies throughout the world.