Ceruloplasmin


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ceruloplasmin

[sə¦rül·ō¦plaz·mən]
(biochemistry)
The copper-binding serum protein in human blood.

Ceruloplasmin

 

a copper-containing protein of the α2-globulin fraction of blood plasma. It was first discovered and isolated by the Swedish scientists C. Holmberg and C. Laurell in 1948. Its content in human plasma is 0.2–0.3 mg/ml. Ceruloplas-min, which has a molecular weight of 130,000, is bound to 60–99 percent of all the plasma copper ions. Its two molecular forms differ in the number of carbohydrate chains, which consist of galactose, mannose, fucose, N-acetylglucosamine, and sialic-acid residues. Ceruloplasmin has some catalytic activity, oxidizing polyamines, polyphenols, and ascorbic acid (vitamin C). It also takes part in hematopoiesis and the transport of copper to sites where other copper-containing proteins, such as cytochromoe oxidases, are synthesized. In addition, it apparently participates in the regulation of the level of biogenic amines.

There exist genetically determined variants of ceruloplasmin caused by the presence of mutant alleles. The level of ceruloplas-min in blood serum increases nonspecifically during pregnancy, infections, anemias, and malignancies but decreases during the Wilson-Konovalov disease and some other diseases.

N. N. CHERNOV

References in periodicals archive ?
The loading of ceruloplasmin levels is the crucial step for copper transport and is the affected process in the pathophysiology of Wilson's disease.
Mouse ceruloplasmin and lysozyme kits were available from Cusabio Biotech Co.
vi) Increased antioxidants such as vitamin E, ceruloplasmin, and erythrocyte thiols and increased ironbinding capacity; otherwise, serum iron concentrations progressively decrease.
Role of external loops of human ceruloplasmin in copper loading by ATP7B and Ccc2p.
The state of nonenzymatic and enzymatic components of AOS was studied on the content of ceruloplasmin, retinol, atocopherol in the blood plasma, as well as reduced glutathione, SOD and catalase activity in erythrocytes with use of spectrophotometric method [16].
Serum ceruloplasmin and urinary copper levels were normal.
Objective To find the serum copper and ceruloplasmin levels in patients of systemic sclerosis and morphoea in the Kashmir Valley.
The predicted amino acid sequence of human hephaestin is 50% identical and 68% similar to the sequence of human ceruloplasmin (Syed, 2002)".
C-ANCA, P-ANCA, alpha1-antitrypsin level, transferrin, ceruloplasmin, and AFP were all normal.
Other explanations to low copper might be that most of the copper will convert to ceruloplasmin.