Boucher of the University of North Carolina at Chapel Hill and his group have shown that in mice bred to develop symptoms of cystic fibrosis, the severity of disease varies from organ to organ depending on the amount of another channel protein
produced by cells in these organs.
VaxInnate's universal influenza vaccine candidate is designed to target the ectodomain of the M2 protein (M2e), an ion channel protein
found on the surface of influenza A viruses.
To further investigate one of the 22 regions deemed significant, team members used mouse hearts to find where in the heart the ion channel protein
products of the SCN10A gene form, locating an abundance of them in the fibers that conduct electrical signals.
The finding directly links the genetic cause of CF-mutations in a channel protein
called cystic fibrosis transmembrane conductance regulator (CFTR) -- to the disruption of a biological mechanism that protects lungs from bacterial infection.
Vical's trivalent vaccine contains the H5 plasmid plus separate plasmids encoding consensus sequences of two highly-conserved influenza virus proteins: nucleoprotein (NP) and ion channel protein
This milestone marks EPIX and CFFT's successful completion of the development of a validated model of a full-length Cystic Fibrosis Transmembrane conductance Regulator (CFTR) ion channel protein
hrough some mechanisms we still don't quite understand, malfunction of this channel protein
eventually leads to bacterial infection in the lung, which is believed to be responsible for the most severe symptoms of cystic fibrosis.
May 21 /PRNewswire-FirstCall/ -- Researchers from Dendreon Corporation today presented preclinical data demonstrating the potential of D-3263, Dendreon's orally bioavailable small molecule, which targets Trp-p8 (a transmembrane cation channel protein
also known as Trp-M8), to treat benign prostatic hyperplasia (BPH).
The most significant variants were found in the gene for KCNN3, a potassium channel protein
that carries signals across cell membranes in organs including the brain and the heart.
Vical's vaccine contains three individual plasmids encoding consensus sequences of two highly-conserved influenza virus proteins -- nucleoprotein (NP) and ion channel protein
(M2) -- and a hemagglutinin (HA) surface protein from the H5N1 influenza virus strain, A/Vietnam/1203/04.
president and chief executive officer of Predix added, "We have reached another milestone in our research program with CFFT, and I want to congratulate our joint development team on their efforts and thank the Predix computational team for their continued progress with modeling the CFTR ion channel protein
TRPC6 is a receptor channel protein
found in most, if not all, cells in the body.