In children being treated for Pb poisoning by EDTA chelation therapy, elevated urinary ALA was significantly associated with higher chelatable
Pb and with a decrease in the chelatable
Zn/Pb ratio to 18.
To determine whether there is an increased mobilizable lead pool, the size of the chelatable
pool in controls must first be measured.
iron, and the regulation of transferrin receptor biosynthesis.
The resulting increase in chelatable
iron would be expected to lead to a down-regulation of transferrin receptor expression (16).
The literature on the health effects of lead exposure also includes studies that have measured chelatable
This regulation occurs by means of an interaction between the iron regulatory protein (IRP)', a molecule that senses changes in the chelatable
intracellular iron pool X14-16], and iron-responsive elements (IREs) located on untranslated regions of ferritin and transferrin receptor mRNAs X16-18].
1997b, 2000) reported chelatable
urinary lead after administration of oral doses of DMSA.
A 4-hr urine collection after oral administration of 10 mg/kg dimercaptosuccinic acid (DMSA) was also obtained to measure DMSA chelatable
lead and creatinine clearance (787 participants completed this collection).