chelerythrine


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chelerythrine

[‚kel·ə′rī‚thrēn]
(organic chemistry)
C21H17O4H A poisonous, crystalline alkaloid, slightly soluble in alcohol; it is derived from the seeds of the herb celandine (Chelidonium majus) and has narcotic properties.
References in periodicals archive ?
Two hours after LPS stimulation, cells influenced by sanguinarine and chelerythrine significantly declined the CCL-2 expression by a factors of 3.
Chelerythrine decreased the level of IL-6 mRNA by a factor of 1.
Sanguinarine (1) and chelerythrine (2) are quaternary benzo[c]phenanthridine alkaloids (QBA) (Figs.
We also show that TGF-[beta]-induced ROS production and TGF-[beta]1 expression require PKC activity as indicated by the inhibition using chelerythrine.
7A illustrates that the inhibition of PKC activity by chelerythrine (10 [micro]M) prevented TGF-[beta]-induced ROS production in [C.
Chelerythrine is currently in pre-clinical development for the treatment of bipolar disorder and the cognitive deficits of schizophrenia.
1) are the benzophenanthridine alkaloids (sanguinarine, chelerythrine and chelidonine) and protoberberines (berberine, coptisine).
The content of the alkaloids chelidonine, protopine, coptisine, berberine, sanguinarine and chelerythrine was quantified by RPHPLC-DAD.
Angoline and chelerythrine, benzophenanthridine alkaloids that do not inhibit protein kinase C.