TG-0054, also known as burixafor, is a novel, potent and selective chemokine
You can mix and match them, but you always need one of each--one selectin, one integrin and one chemokine
, and each one's receptor--for immune cells to go into the brain.
is a clinical-stage biopharmaceutical company focused on discovering, developing and commercializing orally-administered therapeutics that target the chemokine
and chemoattractant systems in order to treat autoimmune diseases, inflammatory disorders and cancer.
However, it is known that receptor internalization is necessary for triggering activation of the signal transduction pathway upon chemokine
binding to the receptor.
Genetic deficiency of chemokine
receptor CCR5 is a strong risk factor for symptomatic West Nile virus infection: a meta-analysis of 4 cohorts in the US epidemic.
receptors are G protein-coupled receptors that are best known for their involvement in providing leukocyte trafficking in response to chemokine
The data published results from ChemoCentryx's extensive chemokine
drug discovery capabilities and insights into chemokine
Traficet-EN, a small molecule, orally-available drug, is intended to control the inappropriate immune system response underlying inflammatory bowel disease (IBD) by blocking the activity of the CCR9 chemokine
Based on a clinical scenario, Chemokine
said patients might be able to receive aggressive chemotherapy without delay by restoring infection-fighting white blood cells and increasing platelet counts to protect patients from bleeding, and/or increase in blood stem cells suitable for transplant.
Stelic believes that administration of an effective dose of a specific neutralizing agent for chemokine
CXCL10 will offer a new treatment by means of promoting the histological and functional repair of hepatic cells.
While HIV has subverted the chemokine
receptors CCR5 and CXCR4 for its own use as an entry co-receptor, their normal functions are to transduce signals in response to extracellular ligands.
HIV-1 infection requires the sequential binding of the viral envelope glycoprotein gp120 to the cell surface receptor CD4 and then to a cellular coreceptor belonging to the chemokine
family of receptors.