Genetic deficiency of chemokine receptor CCR5
is a strong risk factor for symptomatic West Nile virus infection: a meta-analysis of 4 cohorts in the US epidemic.
SCH-C (SCH351125), an orally bioavailable, small molecule antagonist of the chemokine receptor CCR5
is a potent inhibitor of HIV-1 infection in vitro and in vivo.
CXCR4, and another chemokine receptor CCR5
, are involved in HIV infection.
In the study, the researchers demonstrate that the chemokine CCL5 helps to direct the recruitment of EPCs to sites of wounding by acting on the chemokine receptor CCR5
The study was carried out on 14 patients with histopathologically confirmed head and neck squamous cell carcinoma (HNSCC) and ten healthy individuals (control) matched for age to determine the following : (i) The status of CC chemokine receptor CCR5
and its ligands MIP-1[alpha] and RANTES