chimerism


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Related to chimerism: blood chimerism

chimerism

[′kī·mə‚riz·əm]
(biology)
The admixture of cell populations from more than one zygote.
References in periodicals archive ?
We describe a novel use of ubiquitous CNVs, specifically copy number deletion (CND) polymorphisms, for highly accurate quantification of plasma DNA chimerism.
chimerism instead results from the fusion of multiple fertilized zygotes, and these conditions have been reported for a number of chromosomal aberrations, from aneuploidy to CNVs.
Disputed Maternity Leading to Identification of Tetragametic Chimerism," New England Journal of Medicine 346 (2002): 1545-52.
They and their colleagues were the first to translate transplant tolerance through mixed chimerism from bench to bedside and together, their work has been regarded as the first successful trial in humans of intentional solid organ tolerance induction.
Chimerism and mosaicism are two examples of this phenomenon.
He performs DNA fingerprinting and chimerism (a state in which a person has more than one set of DNA) studies in patients undergoing bone marrow transplantation (BMT) and monitoring studies following BMT.
17 resembles that of sequences from patients TV721 and TV749 in terms of chimerism, but the location of recombination breakpoints is distinct (data not shown).
Chimerism is the co-existence of more than one genetically distinct cell population, derived from more than one fertilized egg, in a single organism.
She examines attitudes and policies, both for and against, regarding research in the areas of chimerism (combining cells from two individuals of different species), hybridization (combining human and nonhuman eggs and sperm), interspecies nuclear transfer (transferring a human cell nucleus to an enucleated animal egg in order to study developmental biology), cross-species embryo transfer, and transgenics (splicing human DNA to nonhuman embryos, which is common, or splicing nonhuman DNA to human embryos, which is not on the horizon).
Significantly, the isolated cells can produce high rates of chimerism when reintroduced into early stage embryos and can transmit through the germline, they report.
Additionally, where natural-born children do not have the same DNA as their parents because of chimerism, DNA testing may be inconclusive.
With an approach called isotype chimerism, in which portions of IgG3, an antibody's isotype, are introduced into corresponding regions of IgG1, the standard isotype for therapeutic antibodies, COMPLEGENT(TM) Technology significantly enhances CDC activity beyond that of either IgG1 or IgG3, while retaining the desirable features of IgG1, such as ADCC, PK profile and Protein A binding.