chlorpropamide


Also found in: Dictionary, Medical, Wikipedia.

chlorpropamide

[klȯr′prō·prə‚mīd]
(pharmacology)
C3H7NHCONHSO2C6H4Cl A crystalline compound with a melting point of 127-129°C; soluble in alcohol; used in the treatment of diabetes.
References in periodicals archive ?
Chlorpropamide (500 [micro]g/ml, 10 [micro]l) was used as the internal standard for extraction and HPLC analysis.
First generation sulfonylureas, like chlorpropamide, should generally be avoided due to active metabolites and hypoglycemia risk.
While all glucose-lowering agents can cause hypoglycemia, it is most likely to occur with the insulin secretagogues, especially the long-acting sulfonylureas chlorpropamide and glyburide.
Medications currently approved to treat type 2 diabetes, 2010 Mean Maximum daily daily Class Drugs doses doses Biguanide Metformin 850 mg (a) 2 550 mg Sulfonylureas Chlorpropamide 250 mg (b) 500 mg Glibenclamide 5 mg (a) 20 mg Glipizide 5 mg (a) 20 mg Glimepiride 4 mg (b) 8 mg Gliclazide 80 mg (a) 320 mg Gliclazide MR 60 mg (b) 120 mg Meglitinides Nateglinide 60 mg (c) 360 mg Repaglinide 2 mg (c) 12 mg Thiazolidinediones Rosiglitazone 4 mg (a) 8 mg Pioglitazone 30 mg (b) 45 mg a-glucosidase Acarbose 50 mg (c) 300 mg inhibitors Miglitol 25 mg (c) 100 mg DPP-4 inhibitors/ Sitagliptin 100 mg (b) 100 mg gliptines Vildagliptin 50 mg (a) 100 mg Saxaglipnin 5 mg (b) 5 mg Incretine analogues Exenatide 20 mcgr (a) 20 mcgr Liraglutide 1.
The first-generation sulfonylureas currently available are chlorpropamide (Diabinese), tolazamide (Tolinase), and tolbutamide (Orinase).
Glibenclamide ou chlorpropamide en traitement d'un diabete de type 2 (risque d'hypoglycemie prolongee).
In the non-tumoral causes of SIADH, like head trauma, pneumonia, and chlorpropamide therapy, the plasma and urinary AVID concentrations are generally within normal ranges (16).
5 mg qd, and lisinopril, 10 mg qd, for hypertension, chlorpropamide, 250 mg qd, for type 2 diabetes, and aspirin, 160 mg qd, daily.
Chlorpropamide, carbamazepine and clofibrate are similarly used albeit less frequently.
Medications were identified in the prescription drug medication and the analgesics/pain reliever questionnaires, and included estrogens and/or progesterone, other steroid hormones (androgens, adrenal corticosteroids, tamoxifen, raloxifene, and pituitary hormones), nonsteroidal anti-inflammatory drugs (NSAIDs), furosemide, beta-blockers, blood glucose regulators, and other medications thought to affect thyroid hormones (amidoarone, carbamazepine, chlorpropamide, carbidopa/levodopa, heparin, interferon, lithium, phenytoin, phenobarbital, and sulfasalazine).
Common drugs causing immune thrombocytopenia Analgesics salicylates acetaminophen phenylbutazone Antibiotics cephalothin penicillin streptomycin aminosalicylic acid rifampin novobiocin Various sulfa drugs (chlorthalidone, furosemide) Alkaloids Quinidine Quinine Sedatives, anticonvulsants methoin troxidone chlorpromazine diphenylhydantoin meprobamate phenobarbital carbamazepine Oral hypoglycemics chlorpropamide tolbutamide Heavy metals gold mercury bismuth organic arsenicals Miscellaneous chloroquine chlorothiazide insecticides