chlorpropamide


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chlorpropamide

[klȯr′prō·prə‚mīd]
(pharmacology)
C3H7NHCONHSO2C6H4Cl A crystalline compound with a melting point of 127-129°C; soluble in alcohol; used in the treatment of diabetes.
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Chlorpropamide (500 [micro]g/ml, 10 [micro]l) was used as the internal standard for extraction and HPLC analysis.
Medications were identified in the prescription drug medication and the analgesics/pain reliever questionnaires, and included estrogens and/or progesterone, other steroid hormones (androgens, adrenal corticosteroids, tamoxifen, raloxifene, and pituitary hormones), nonsteroidal anti-inflammatory drugs (NSAIDs), furosemide, beta-blockers, blood glucose regulators, and other medications thought to affect thyroid hormones (amidoarone, carbamazepine, chlorpropamide, carbidopa/levodopa, heparin, interferon, lithium, phenytoin, phenobarbital, and sulfasalazine).
Common drugs causing immune thrombocytopenia Analgesics salicylates acetaminophen phenylbutazone Antibiotics cephalothin penicillin streptomycin aminosalicylic acid rifampin novobiocin Various sulfa drugs (chlorthalidone, furosemide) Alkaloids Quinidine Quinine Sedatives, anticonvulsants methoin troxidone chlorpromazine diphenylhydantoin meprobamate phenobarbital carbamazepine Oral hypoglycemics chlorpropamide tolbutamide Heavy metals gold mercury bismuth organic arsenicals Miscellaneous chloroquine chlorothiazide insecticides
xx Actos, Amaryl, Avandamet, Avandia, chlorpropamide, Diabeta, Diabinese, Fortamet, Glipizide, Glipizide ER, Glipizide XL,Glucophage, Glucophage XR, Glucotrol, Glucotrol XL, Glucovance, glyburide, glyburide micronized, glyburide-metformin, Glynase, Glyset, Humalog, Humalog Mix 75/25, Humulin 50/50, Humulin 70/30, Humulin L, Humulin N, Humulin R, Humulin U, Iletin II Lente Pork, Iletin II NPH Pork, Iletin II Regular Pork, Iletin NPH, Lantus, Metaglip, metformin, metformin ER, Micronase, Novolin 70/30, Novolin L, Novolin N, Novolin R, Novolog, Novolog Mix 70/30, Prandin, Precose, Riomet, Starlix, tolazamide, tolbutamide, Tolinase, Velosulin Human BR ED = Erectile dysfunction; ICD-9-CM = International Classification of Diseases, 9th Edition, Clinical Modification; HCTZ = hydrochlorothiazide.
Sulfonylurea therapies included glimepiride 4 mg/day, glipizide 20 mg/day, glipizide XL 10 mg/day, glyburide 10 mg/day, micronized glyburide 6 mg/day, chlorpropamide 350 mg/day, and tolazamide 500 mg/day.
The sulfonylureas were kindly supplied by the following manufacturers: glibenclamide, glimepiride, and tolbutamide by Aventis (Paris, France); glipizide and chlorpropamide by Pfizer (Paris, France); gliclazide and carbutamide by Servier (Neuilly-sur-Seine, France); glibornuride by CSP (Cournon, France); and glisoxepide by Bayer (Puteaux, France).
The exceptions to this rule are chlorpropamide and glyburide, because both have prolonged half-lives and a tendency to cause hypoglycemia.
The primary treatment for nephrogenic DI is cessation of any causative agent and free water replacement, the administration of thiazide diuretics, and the administration of chlorpropamide, which may increase ADH release (Litwack, 1998).
Among the agents on the always-avoid list for elderly patients are meperidine, flurazepam, barbiturates, and chlorpropamide.
The Table 2 presents some results concerning: transdermal form of propranolol ([beta]-blocker) for treatment of patients with cardiovascular diseases; transdermal form of chlorpropamide (hypoglycemic medicine) for patients with non-insulin-dependent diabetes mellitus (Type II) [32]; in vitro results for transdermal form of insulin for patients with insulin dependent diabetes mellitus (Type I).