chlorzoxazone


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chlorzoxazone

[klȯr′zäks·ə‚zōn]
(pharmacology)
C7H4ClNO2 Crystals with a melting point of 191-191.5°C; soluble in aqueous solutions of alkali hydroxides and in ammonia; used as a skeletal muscle relaxant.
References in periodicals archive ?
In this study, the effects of MA on the above-mentioned CYPs activities were also investigated in rat liver microsomes, employing phenacetin (CYP1A2), tolbutamide (CYP2C11), dextromethorphan (CYP2D6), chlorzoxazone (CYP2E1) and testosterone (CYP3A2) as the probe substrates.
Effects of cigarette smoking and carbon monoxide on chlorzoxazone and caffeine metabolism.
Human lymphocyte cytochrome P4502E1, a putative marker for alcohol-mediated changes in hepatic chlorzoxazone activity.
The reactions, including phenacetin-0-deethylation, tolbutamide 4-hydroxylation, dextromethorphan 0-demethylation, chlorzoxazone 6-hydroxylation and testosterone 6[beta]-hydroxylation, were used for detecting activities of CYP1A2, CYP2C9, CYP2D6, CYP2E1 and CYP3A4, respectively.
Hydroxylation of chlorzoxazone as a specific probe for human liver cytochrome P450IIE1.
The effect of PSP on the human CYP isoforms was investigated to determine the potential of PSP in affecting CYP medicated phase I metabolism in man, using phenacetin (CYP1A2), dextrophan (CYP2D6), chlorzoxazone (CYP2E1) and testosterone (CYP3A4) as the respective model probe substrates.
Phenacetin, paracetamol, metacetamol, furafylline, testosterone, 6[beeta]-hydroxytestosterone, corticosterone, ketoconazole, tolbutamide, chlorpropamide, 4-hydroxytolbutamideT chlorzoxazone, 6-hydroxychlorzoxazone, sodium diethyl-ditbiocarbamate D-glucose 6-phosphate (G6P), glucose 6-phosphate dehydrogenase (G6PDH), [beeta]-nicotinamide adenine dinucleotide phosphate (NADP), and Tris-HCl were purchased from Sigma Chemical Co.
However, another study showed the decreased oral clearance of chlorzoxazone with RasI homozygous variants in Japanese residents of Hawaii (Marchand et al.
Tanshinone IIA selectively inhibited CYPlA-catalysed EROD and MROD activities in rat liver microsomes, without affecting other P450-catalysed oxidations such as benzo(a)pyrene, tolbutamide, chlorzoxazone and nifedipine, which are substrates for CYP2E1, 2C and 3A (Ueng et al.
Tenders are invited for Tab/ Cap Containing Chlorzoxazone 500Mg Plus Diclofenac Sodium 50Mg Plus Paracetamol 500Mg In Strip
6] Substrate s-Mephenytoin Dextro- Chlorzoxa- methorphan zone Concentration 20 [micro] 8 [micro] 100 [micro] Source BioMol Sigma ICN Research Biomedicals Metabolite 4-OH Dextror- 6-OH s-Mephenytoin phan Chlorzoxazone Source BioMol Sigma ICN Research Biomedicals Positive Control Omeperazole Quinidine 4-Methyl pyrazole Concentration 25 [micro]M 2.