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Causes of cholestatic jaundice in a cohort of 74 patients Cause N Biliary atresia 39 (27 evaluable) Non-biliary atresia 34 (31 evaluable) Neonatal hepatitis 10 Choledochal cyst 9 Viral enterocolitis 5 HIV hepatitis 3 Gallstones 1 Auto-immune 1 Miscellaneous 2
In rare cases within the first few weeks of therapy, this drug can cause severe and reversible cholestatic jaundice.
Since that time, few cases of severe cholestatic jaundice have been described in association with use of the drug.
HEPATIC INJURY, manifested as elevation of transaminases or cholestatic jaundice or both, has been associated with many drugs.
Caution should be exercised in patients with hypertriglyceridemia, impaired liver function or a history of cholestatic jaundice, conditions that might be influenced by fluid retention, hypocalcemia, asthma, diabetes mellitus, epilepsy, migraine, porphyria, systemic lupus erythematosus, and hepatic hemangiomas.