Keywords: Catharanthus roseus roots Catharanthine Ajmalicine Serpentine Acetylcholinesterase Cholinergic Receptors
That receptor, which contains the nicotinic a-7 cholinergic receptor
subunit, is necessary to inhibit the release of TNF and other pro-inflammatory cytokines.
The first is independent of cholinergic receptor
expression and influences cell replication through effects on intracellular messengers (9,12,14).
The inhibition of these enzymes increases the availability of Ach, which in turn can stimulate cholinergic receptors
producing both nicotinic and muscarinic effects in the organism such as muscle contractions and secretions in many glands (5).
QUEBEC CITY, Quebec, June 18, 2014 /PRNewswire/ -- Asmacure Ltee, a clinical-stage biopharmaceutical company focused on the development of novel, proprietary compounds that target cholinergic receptors
for the treatment of pulmonary diseases, today announced top-line results from a combined Phase 1 and 2a trial evaluating its lead compound, ASM-024, in moderate asthma patients.
HET] mice have reduced ACh transmission by central cholinergic neurons (22), compensatory mechanisms, such as supersensitivity of cholinergic receptors
, could account for the normal sleep-wake physiology.
Ipratropium bromide, which is used frequently as a bronchodilator in patients with bron-chospasm, is a direct antagonist of muscarinic cholinergic receptors
Expression and distribution of cholinergic receptors
in the human urothelium.
to polybrominated diphenyl ether (PBDE 153) disrupts spontaneous behaviour, impairs learning and memory, and decreases hippocampal cholinergic receptors
in adult mice.
Nondepolarizing agents cause muscle paralysis by affecting the postsynaptic cholinergic receptors
at the neuromuscular junction.
Haley and his colleagues reasoned that if low-level satin or pesticides had damaged Gulf Was Veterans' brains, a likely target of the damage would be cholinergic receptors
on cells in certain brain structures.
Nicotinic cholinergic receptors
have been demonstrated on keratinocytes, which may control keratinocyte adhesion and upward migration in the epidermis," Dr.