chordoma


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chordoma

[kȯr′dō·mə]
(medicine)
A rarely malignant tumor derived from persistent remnants of the notochord.
References in periodicals archive ?
Extraskeletal myxoid chondrosarcoma and conventional chondrosarcoma of bone usually can be distinguished from primary or metastatic chordoma if clinical, radiologic, and histomorphologic features are taken into account.
Latz et al described the outcomes of 13 patients whose clival chordomas were treated with 3D-CRT to a median dose of 70 Gy.
The responses to treatment were the most spectacular remissions that we have ever seen in chordoma patients," said Dr.
The biopsy revealed trabecular bone and marrow fat replaced by malignant tumour, in-keeping with chordoma, not the presumed diagnosis of renal cell carcinoma.
Although chordomas are slow growing, they can cause pain, paralysis, problems with vision, swallowing and death.
However, intralesional calcifications are much more suggestive of chordoma.
In the differential diagnosis, metastases, lymphoma, multiple myeloma, chordoma sarcoidosis and rare spinal infections such as brucellosis and fungal disease were considered.
Predominantly found in people 50-69 year old, a chordoma arises found remnants of the primitive notochord.
3, 2012, the sinus trouble Pagan attributed to allergies was diagnosed as an extremely rare tumor, clival chordoma, at the base of his skull.
Several organizations have signed on as #authenticate champions in advance of the campaign launch, noting their support for the campaign goals, including the Rare Cancer Research Foundation, the Chordoma Foundation, CellBank Australia, the International Cell Line Authentication Committee, Melanoma Research Alliance, and the Prostate Cancer Foundation.
Immunohisto-chemical analysis can differentiate a chondrosarcoma from a chordoma; chondrosarcomas contain vimentin, and chordomas contain keratin.
Loss or alteration to PTEN, a common tumor suppressor gene, was observed in up to 80 percent of subtypes, including osteosarcoma, rhabdomyosarcoma, epithelioid sarcoma, Ewings sarcoma, alveolar soft part sarcoma and chordoma Clinical trials are options for patients with absent or altered PTEN in these subtypes.