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(kərē`ə, kō–) or

St. Vitus's dance,

acute disturbance of the central nervous systemnervous system,
network of specialized tissue that controls actions and reactions of the body and its adjustment to the environment. Virtually all members of the animal kingdom have at least a rudimentary nervous system.
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 characterized by involuntary muscular movements of the face and extremities. The disease, known also as Sydenham's chorea (not to be confused with Huntington's diseaseHuntington's disease,
hereditary, acute disturbance of the central nervous system usually beginning in middle age and characterized by involuntary muscular movements and progressive intellectual deterioration; formerly called Huntington's chorea.
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, a hereditary disease of adults that is sometimes called Huntington's chorea), is usually, but not always, a complication of rheumatic feverrheumatic fever
, systemic inflammatory disease, extremely variable in its manifestation, severity, duration, and aftereffects. It is frequently followed by serious heart disease, especially when there are repeated attacks. Rheumatic fever usually affects children.
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. Sydenham's chorea, a disease of children, especially females, usually appears between the ages of 7 and 14. Facial grimacing and jerking movements persist for 6 to 10 weeks and sometimes recur after months or even years. Eventually the symptoms disappear. Although there is no specific treatment, sedatives and tranquilizers are helpful in suppressing the involuntary movements. Technically, it is sometimes called chorea minor or juvenile chorea to distinguish it from several less common choreas, chorea also being a general term for continuous, involuntary jerking movements.



a form of hyperkinesia characterized by rapid movements such as twitching of the extremities, winking, and smacking of the lips. It is associated with organic injury to certain subcortical sections of the brain. The most common form is chorea minor, or Sydenham’s chorea, usually found in children and adolescents as an indication of rheumatism. In addition to hyperkinesia, other characteristics of chorea are low muscle tone and such asthenic symptoms as sleeplessness, lacrimation, and irritability. Sydenham’s chorea usually takes a favorable course, but recurrences are possible. The condition known as chorea major, marked by hysterical choreiform twitchings that were observed as a mass phenomenon in the Middle Ages, is now of historical interest only.

Huntington’s chorea (described in 1872 by the American psychiatrist G. Huntington) is a hereditary degenerative disease transmitted as an autosomal dominant trait. It usually occurs between the ages of 35 and 40 and is characterized by chronic progressive deterioration. Muscle tone is low in some cases, and high (with muscular rigidity) in others. The principal characteristics of Huntington’s chorea are such forms of mental deterioration as apathy, loss of memory, intellectual decline, transient delusions, hallucinations, and the gradual development of severe dementia. Other findings in Huntington’s chorea include subcortical lesions and atrophy of the brain cortex.

Sydenham’s chorea is treated with antirheumatic drugs (including salicylates), sedatives, and antiallergens (such as diphenhydramine and chloropyramine). Chlorpromazine and reserpine are prescribed for Huntington’s chorea; drugs used in the case of muscular rigidity include cholinolytic agents (such as trihexyphenidyl hydrochloride), L-dopa, and amantadine hydrochloride.


Anosov, N. N. “Khoreia Khantingtona.” In Mnogotomnoe rukovodstvopo nevrologii, vol. 7. Leningrad, 1960.
Tsuker, M. B. Infektsionnye zabolevaniia nervnoi sistemy u detei. Moscow, 1963.
Hittyk, L. S. Mala khoreia. Kiev, 1965.



A nervous disorder seen as part of a syndrome following an organic dysfunction or an infection and characterized by irregular, involuntary movements of the body, especially of the face and extremities.


a disorder of the central nervous system characterized by uncontrollable irregular brief jerky movements
References in periodicals archive ?
A literature review revealed that the onset of chorea in cases of BD varied from the time of onset of BD to 31 years after the onset of the disease (3).
3%), specifically carditis plus chorea in 3, carditis plus arthritis in 1 and carditis plus subcutaneous nodules in 1.
Inspired by chorea, "Out of Context" played at Masrah al-Madina Friday as part of the Beirut International Platform of Dance (BIPOD), courtesy of the Goethe Institute and Beiteddine Festival.
Sodium valproate has been recommended as treatment where trials with haloperidol have failed and the chorea remains severe.
They are present in disorders such as Huntington's chorea and are associated with certain medications and neurological injury.
Cambridge Laboratories Group Limited ("Cambridge"), the privately-owned specialty pharmaceutical company, today announces that XENAZINE(R) (tetrabenazine), the first and only product approved for the treatment of chorea associated with Huntington's disease, has been launched in the US.
Tetrabenazine (Xenazine), the first treatment of any kind to be approved in the United States for the disease, also is the first drug to be approved by the agency for the treatment of chorea.
4) It has been proposed that an immune mediated mechanism similar to that in Sydenham chorea occurs, in which antibodies produced against GABHS cross-react with neuronal tissue in the basal ganglia.
Bicillin[R] L-A is also indicated for mild-to-moderate infections of the upper respiratory tract due to susceptible streptococci, including streptococcal pharyngitis, and has been used for prophylaxis to prevent recurrence of rheumatic fever and/or chorea.
The sea urchin has many genes linked to human diseases such as Huntington's chorea, muscular dystrophy, Usher syndrome, neurological disorders, and atherosclerosis.
Then her father is diagnosed with Huntington's Chorea and suddenly it feels as though everything she has always held dear has come crashing down all around her.