To evaluate the cytotoxic effect in cultured chromaffin cells
, LDH release assay has been used by (Sicard et al.
The cells, called chromaffin cells
, have large vesicles, 200 nanometers (nm) across.
Lesions may occur in multiples along the extra-adrenal chromaffin cell
system; 40%-50% of all patients with an autosomal dominant familial variant will demonstrate multiple lesions.
Lazorthes Y, Sagen J, Sallerin B, Tkaczuk J et al, "Human Chromaffin Cell
Graft into the CSF for Cancer Pain Management: A Prospective Phase II Clinical Study", Pain, 2000, Jul.
Lumbar intrathecal transplant is easiest in humans and was used in all the earlier adrenal chromaffin cell
therapy for chronic pain in humans [82-83].
of the adrenal medulla are derived from multipotent neural crest cells in the developing embryo.
Tympanic paragangliomas are neuroendocrine neoplasms located in the middle ear and arising from chromaffin cells
of the parasympathetic paraganglia.
A phaeochromocytoma is a rare neuro-endocrine tumour of the paraganglionic chromaffin cells
affecting 2-8 persons per million per year.
PCC and paraganglioma (PGL) are rare neuroendocrine tumors arising from chromaffin cells
The specific aims of this proposal are: 1) to characterize the alpha6-containing nAChR subtype(s) present in human adrenal chromaffin cells
and to investigate the regulation of their expression by nicotine; 2) to study the functional interaction between alpha6beta4 nAChRs and mitochondria; 3) the regulation of this nAChR subtype by mitochondrial ROS.
Because of its association with amine/ peptide secretory materials, CGA is expressed in chromaffin cells
(adrenal medulla, paraganglia, among others), enterochromaffin-like cells, and b cells of the pancreas but not in steroid hormone producing cells (adrenal cortex, gonads, for instance).
Pheochromocytomas and catecholamine-secreting paragangliomas, also referred to as extraadrenal pheochromocytomas, are rare neuroendocrine tumors that arise from chromaffin cells
of the adrenal medulla and sympathetic ganglia.