chromomycin

chromomycin

[¦krō·mō′mī·sən]
(microbiology)
Any of five components of an antibiotic complex produced by a strain of Streptomyces griseus; components are designated A1 to A5, of which A3(C51H72O32) is biologically active.
References in periodicals archive ?
9 [micro]M) were the most potent compounds in this group; aclarubicin hydrochloride, plicamycin, and the structurally related chromomycin A3 were also active, whereas adriamycin hydrochloride was inactive.
The GC and AT rich regions were detected using the fluorochromes Chromomycin [A.
Several tests such as TdT (terminal deoxyribonucleotidyl transferase)-mediated dUTP nick-end labeling (TUNEL) assay, aniline blue straining, chromomycin A3 and acridine orange (AO) staining have been described to determine the extent of DNA damage.
Evaluation of sperm's chromatin quality with acridine orange test, chromomycin A3 and aniline blue staining in couples with unexplained recurrent abortion.
Additionally, for detection of the AT- and GC- rich chromatin regions, some chromosomal preparations were stained with the fluorochromes 4'-6-diamidino-2-phenylindole (DAPI) and chromomycin [A.
Staining with aniline blue, toludine blue, and chromomycin A3 is used to identify sperm chromatin packaging defects.
The antiproliferative activity of these compounds was found to be comparable to that of known antitumor agents, including cisplatin, chromomycin, cytosine arabinoside and 5-fluorouracil.
1 mL) were frozen and stored at -70[degress]C for later analysis of chromatin integrity by the sperm chromatin structure assay (SCSA; Evenson and Jost 2000) and for chromatin maturity by chromomycin A3 (CMA) staining (Sakkas et al.
Also, we can use chromomycin A3 (CMA3), toluidine blue (TB) or aniline blue (AB) to detect the sperm chromatin integrity/maturity (30, 31).
2000 Sperm count surrogate Anderson and Sharpe 2000 Abbreviations: CMA3 staining, chromomycin A3 staining; COMET, single-cell gel electrophoresis assay; FISH, fluorescence in situ hybridization; SCSA, sperm chromatin structure assay; TUNEL, terminal deoxynucleotidyl trans-ferase-mediated dUTP-biotin end-labeling.
Other antibiotics such as chromomycins (Dactinomycin and Plicamycin) and a miscellaneous group Mitomycin and Bleomycin are also used.