cisplatin


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cisplatin

[¦sis′plat·ən]
(medicine)
A transition-metal complex that is used in the treatment of cancer, with particular effectiveness in the treatment of testicular and ovarian cancers; second- and third-generation variants of this drug have been developed to mitigate undesirable side effects.
References in periodicals archive ?
Salicylate reduces cisplatin nephrotoxicity by inhibition of tumor necrosis factor-[alpha].
By comparison, 80% of patients in the cisplatin group responded overall, with 38.
All 24 patients had measurable hearing loss that occurred as early as weeks after beginning cisplatin therapy.
SQUIRE was an open-label, randomized, multi-center Phase III trial that compared first-line treatment with Portrazza in combination with gemcitabine and cisplatin to treatment with gemcitabine and cisplatin alone in patients with metastatic squamous NSCLC.
After the monolayers attained confluency of around 70%, cells were treated with cisplatin (30 [micro]M) with or without Aa-EE (1 or 5 [micro]g/ml).
By using our cisplatin formulation, we can increase the drug dosing to almost double," Dr Basu said.
Finally, of the cisplatin cases, 8 were bilateral and 2 cases were unilateral, for a total of 18 ears.
He and colleagues in London and Manchester examined data for cisplatin combined with radiotherapy and compared it with that for patients given radiotherapy on its own.
Comment: The clinical use of cisplatin chemotherapy is limited by severe peripheral neurotoxicity, which occurs in up to 90% of patients receiving a cumulative dose greater than 300 mg/m2 of body surface area.
Damage is much more common with cisplatin than with a related third-generation platinum compound, oxaliplatin, although the reason has been unknown.
The UK National Cancer Research Institute's Phase III REAL-2 study demonstrated that capecitabine is non-inferior to 5-FU and oxaliplatin is non-inferior to cisplatin when substituted within the ECF regimen.