cisplatin


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cisplatin

[¦sis′plat·ən]
(medicine)
A transition-metal complex that is used in the treatment of cancer, with particular effectiveness in the treatment of testicular and ovarian cancers; second- and third-generation variants of this drug have been developed to mitigate undesirable side effects.
References in periodicals archive ?
Expression of LINC00261 was involved in cisplatin effect on colon cancer cells
In most areas of the body, cisplatin is eliminated within days or weeks after treatment, but in the inner ear, the drug remains much longer.
Neurotoxic effects induced by cisplatin includes increased oxidative-nitrosative stress, proinflammatory cytokines, mitochondrial dysfunction, DNA damage and apoptotic cell death resulting in multiple morphological changes in the neurons such as axonal shrinkage and demyelination (Tuncer et al.
Cisplatin exerts its nephrotoxic effect mainly in the proximal tubular cells where it is preferentially accumulated5.
We mainly tried to analyze two important and widely used chemotherapy combinations of paclitaxel with carboplatin or gemcitabine with cisplatin in treating NSCLC.
In the case of cisplatin, below are 12 studies the majority demonstrating that omega-3 fatty acids enhance the effectiveness of cisplatin or no reduction in efficacy.
This observation study was designed with the primary aim of comparing the efficacy and safety of cisplatin and carboplatin in patients with oral cancers, and it was observed that there was no significant difference in the efficacy between both the drugs, but there was an increase in the adverse effects in the cisplatin group when compared with the carboplatin group.
Patients receiving drugs known to cause ototoxicity other than cisplatin, patients with otitis media with effusion, tympanic membrane perforation, otosclerosis with conductive hearing loss and patients with concomitant neurological, psychological or medical disorders making them unsuitable for treatment or follow-up as per protocol were excluded from the study.
For instance, absorbance spectroscopy was recently shown as an extremely useful tool for studying the interactions of cisplatin with proteins, with a proven advantage of offering direct information on the nature of the Pt-protein adducts formed [4].
Effect of Low Radiation Dose on Cisplatin Induced Hepato- Testicular Damage in Male Rats.
The dosage of cisplatin can be decreased without reduction in its therapeutic effects by using this nanocarrier, which results in decreasing its toxicity.