class switch


Also found in: Medical.

class switch

[′klas ‚swich]
(immunology)
A switch of B-lymphocyte expression from one antibody class to another.
References in periodicals archive ?
Honjo's group had earlier determined that the AID gene is activated in cells when class switch recombination occurs, but was unable to confirm the phenomenon in experiments until now.
In this experiment, the research team used artificially-synthesized mouse cells, which they had determined were unable to undergo class switch recombination without the presence of AID.
Without class switch recombination, we wouldn't be able to send antibodies across the gastrointestinal tract or into the lungs," notes Michael R.
Lieber speculates that a fuller understanding of the process may help thwart Burkitt's lymphoma, a cancer of immune cells that occurs when class switch recombination goes awry.