classical pathway


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Related to classical pathway: alternative pathway, Complement system

classical pathway

[¦klas·i·kəl ′path‚wā]
(immunology)
The pathway by which antigen-antibody complex activates the complement system.
References in periodicals archive ?
However, with regard to Jass' subtype 3, it is unclear whether CRCs arise from the classical pathway or the serrated neoplasia pathway.
65 U/mL) in hemolytic activity in the classical pathway (p = 0.
Both CRP isoforms have the ability to interact with C1q, activating the classical pathway [73, 74].
Serum lectin with known structure activates complement through the classical pathway.
This effect was not achieved by mimicking the classical pathway of insulin action, but by activating the enzyme AMP-activated protein kinase (AMPK).
While these two pathways differ from the classical pathway in their initial activation, all three complement pathways converge to similar outcomes.
The complement-activating polysaccharides found in medicinal plants are grouped into pectic polysaccharides (pectins, pectic arabinogalactans, and pectic herteroglycans), arabinogalactans, arabinans and other types such as mucilage, and it is suggested that they activate the complement system mainly through the classical pathway (Yamada and Kiyohara, 1999).
Individual chapter topics include the building blocks of the complement system, the classical pathway C1 complex, structure-function relationships in CD59, and cyclic antagonists of human C5a receptors.
However, the predominant component was C3, the initiator of the complement cascade via the classical pathway.