Hypothesis: EUG promotes a burst in ROS production causing cell-cycle perturbations, mitochondria toxicity and clastogenesis triggering apoptosis in melanoma breast- and cervix-cancer cells in vitro.
Results: The results obtained herein pointed out that EUG promotes, increasing ROS production leading to abrogation of G2/M of phase of cell-cycle, and consecutively, clastogenesis in vitro.
Attia, "The impact of quercetin on cisplatin-induced clastogenesis
and apoptosis in murine marrow cells," Mutagenesis, vol.
Metabolic activation systems containing 9000g supernatant fraction (S9) of liver homogenates prepared from polychlorinated biphenyl or phenobarbital plus 5,6-benzoflavonepretreated rats were required for mutagenesis and clastogenesis
In this review, the scope has been confined to actual data obtained from research on the modulatory effects of plant extracts on mutagenesis and clastogenesis
- two genotoxic phenomena associated with carcinogenesis.
Bianchi, "Effects of the antioxidants curcumin and vitamin C on cisplatin-induced clastogenesis
in Wistar rat bone marrow cells," Mutation Research, vol.
Several potential carcinogenic mechanisms have been proposed, including inhibition of DNA repair enzymes, tumor promoter-like induction of proliferation, alteration of DNA methylation, and clastogenesis
5 g/L) or high concentrations, where gene mutations and clastogenesis
has been observed in several test systems (Chang et al.