clathrin


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clathrin

[′klath·rən]
(cell and molecular biology)
A protein that forms a lattice-shaped coating, through the assembly of subunits called triskelions, on the cytosolic side of membrane regions called coated pits during the initial stages of receptor-mediated endocytosis. Invagination of the pit results in a clathrin-coated vesicle.
References in periodicals archive ?
10) Human genes: CLU, clusterin; apoe, apolipoprotein E; picalm, phosphatidylinositol-binding clathrin assembly protein; APP, amyloid beta (A4) precursor protein; PSEN 1, presenilin 1; PSEN 2, presenilin 2; BIN 1, bridging integrator 1; CR1, complement component (3b/4b) receptor 1 (Knops blood group).
Endocytosis of CT may follow one of three pathways: (i) lipid raft/caveolae mediated endocytic pathway, (ii) clathrin mediated endocytic pathway, or (iii) ADP-ribosylation factor 6 (Arf6)-associated endocytic pathway.
endoplasmic reticulum, Golgi apparatus and clathrin coated vesicles [24-26].
A protein called clathrin, which is found in every human cell and plays a critical role in transporting materials within them, also plays a key role in cell division, according to new research at the University of California, San Francisco.
1); amino-terminus of 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase gene (ATIC, 2q35); TRK-fused gene (TFG, 3q21), with 3 variants depending on the length (short, long, extra-long); clathrin heavy polypeptide gene (CLTC, 17q23); moesin gene (MSN, Xq11-12); myosin heavy chain 9 gene (MYH9, 22q11.
Clathrin is the major protein component involved in receptor-mediated endocytosis (25).
Indeed, these observations were followed by the discovery of TPM3-ALK and TPM4-ALK fusion oncogenes in IMTs that transform, in vivo, both mesenchymal and lymphoid human cell lineages, as well as clathrin heavy chain gene, CLTC.
Also, OTR desensitization has been able to be inhibited by dynamin and clathrin mutants in human embryonic kidney (HEK) 293 cells (41), as well as by concanavalin A (34), a lectin-type protein that reacts with specific sugar residues.
Subsequently, the phosphorylated lysosomal enzymes bind tightly and specifically to a receptor, the mannose 6-phosphate receptor, a transmembrane protein of the trans Golgi, which directs the enzymes into vesicles coated with clathrin.
nrb]), and clathrin heavy-chain (CLTC) genes, respectively, situated on chromosomes 1q21, 17q25, 1p34, Xq12, and 17q23 (Table 1).

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