clathrin-coated pit

clathrin-coated pit

[¦klath·rən ‚kōd·əd ′pit]
(cell and molecular biology)
A partially invaginated membrane structure (bud or pit) involved in receptor-mediated endocytosis consisting of a cluster of receptor proteins attached on the cytosolic side by means of adaptin molecules to the protein clathrin, which forms a lattice-shaped coating. Complete invagination of the pit and release from the membrane results in a clathrin-coated vesicle containing cargo molecules.
References in periodicals archive ?
r] 160 000) is transported to the cell surface where it clusters in clathrin-coated pits (4).
Sequence variations that encode receptors that move to the cell surface and bind LDL normally but are unable to cluster in clathrin-coated pits are denoted class 4 sequence variations (6, 12).
Class 4 mutant LDLRs have been described to be unable to assemble in clathrin-coated pits (24).
Y828C mutant receptor was not localized in clathrin-coated pits.

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