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Related to clonal: clonal expansion, Clonal selection, Clonal anergy

clone,

group of organisms, all of which are descended from a single individual through asexual reproduction, as in a pure cell culture of bacteria. Except for changes in the hereditary material that come about by mutationmutation,
in biology, a sudden, random change in a gene, or unit of hereditary material, that can alter an inheritable characteristic. Most mutations are not beneficial, since any change in the delicate balance of an organism having a high level of adaptation to its environment
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, all members of a clone are genetically identical. In 1962 John GurdonGurdon, Sir John Bertrand,
1933–, British biologist, Ph.D. Oxford, 1962. He has been a researcher at Cambridge since 1971. Gurdon was the joint recipient of the 2012 Nobel Prize in Physiology or Medicine with Shinya Yamanaka for the discovery that mature cells can be
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 was the first to clone an animal when he transferred cell nuclei from adult frog intestinal cells and injected them into egg cells from which the nucleus had been removed; the eggs then developed into tadpoles. Laboratory experiments in in vitro fertilizationin vitro fertilization
(IVF), technique for conception of a human embryo outside the mother's body. Several ova, or eggs, are removed from the mother's body and placed in special laboratory culture dishes (Petri dishes); sperm from the father are then added, or in many cases a
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 of human eggs led in 1993 to the "cloning" of human embryos by dividing such fertilized eggs at a very early stage of development, but this technique actually produces a twin rather than a clone. In a true mammalian clone (as in Gurdon's frog clone) the nucleus from a body cell of an animal is inserted into an egg, which then develops into an individual that is genetically identical to the original animal.

Later experiments in cloning resulted in the development of a sheep from a cell of an adult ewe (in Scotland, in 1996), and since then rodents, cattle, swine, and other animals have also been cloned from adult animals. Despite these trumpeted successes, producing cloned mammals is enormously difficult, with most attempts ending in failure; cloning succeeds 4% or less of the time in the species that have been successfully cloned. In addition, some studies have indicated that cloned animals are less healthy than normally reproduced animals.

In 2001 researchers in Massachusetts announced that they were trying to clone humans in an attempt to extract stem cellsstem cells,
unspecialized human or animal cells that can produce mature specialized body cells and at the same time replicate themselves. Embryonic stem cells are derived from a blastocyst (the blastula typical of placental mammals; see embryo), which is very young embryo that
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. The National Academy of Sciences, while supporting (2001) such so-called therapeutic or research cloning, has opposed (2002) the cloning of humans for reproductive purposes, deeming it unsafe, but many ethicists, religious and political leaders, and others have called for banning human cloning for any purpose. South Korean scientists announced in 2004 that they had cloned 30 human embryos, but an investigation in 2005 determined that the data had been fabricated. In 2013 scientists at Oregon Health and Science Univ. reported that they had created embryonic stem cells using genetic material from human skin cells and donated eggs; the technique used to create the embryo, however, would not result in a viable human clone.

Bibliography

See G. Kolata, Clone (1997).

Clone

 

several successive generations of hereditarily similar organisms (or individual cells in cultures), formed as a result of asexual or vegetative reproduction from a common ancestor.

Isolating a clone is one of several ways of obtaining genotypically uniform material. However, because of possible mutations, the genotypic homogeneity of a clone is relative. The varieties of plants cultivated vegetatively (for example, the potato) are often individual clones.

In microbiology and protistology, a clone is the set of progeny of a single parental cell.

clone

[klōn]
(biology)
All individuals, considered collectively, produced asexually or by parthenogenesis from a single individual.
(computer science)
A hardware or software product that closely resembles another product created by a different manufacturer or developer, in operation, appearance, or both.
(genetics)
An organism whose diploid nuclear genome was derived from a somatic cell of another organism of the same species using biotechnologys.
A copy of a genetically engineered DNA sequence.

clone

One of a series of plants that is reproduced by cuttings or other vegetative methods for several generations.

clone

1. Biology a group of organisms or cells of the same genetic constitution that are descended from a common ancestor by asexual reproduction, as by cuttings, grafting, etc., in plants
2. a segment of DNA that has been isolated and replicated by laboratory manipulation: used to analyse genes and manufacture their products (proteins)

clone

(jargon)
1. An exact copy of a product, made legally or illegally, from documentation or by reverse engineering, and usually cheaper.

E.g. "PC clone": a PC-BUS/ISA, EISA, VESA, or PCI compatible x86-based microcomputer (this use is sometimes misspelled "klone" or "PClone"). These invariably have much more bang per buck than the IB PCM they resemble.

E.g. "Unix clone": An operating system designed to deliver a Unix-like environment without Unix licence fees or with additional "mission-critical" features such as support for real-time programming.

2. <chat> A clonebot.

clone

(1) To make an identical copy of something. See cloning software.

(2) A product that functions like another. The clone, which may be hardware, software or both, may not look exactly like the original, but it implies 100% functional compatibility with it. Fed the same input, the clone should produce the same output. See PC clone, white box and clean room technique.
References in periodicals archive ?
The discovery was enabled by the combination of MPOB's and the oil palm industry's vast collection of highly characterized clonal palms with a solid knowledge of oil palm and tissue culture and Orion's MethylScope technology, a tool used to precisely map DNA methylation across entire genomes.
Systemic mastocytosis with associated clonal hematologic nonmast cell lineage disease: a clinicopathologic review.
Analysis of the genotypes by eBURST showed that 26 genotypes clustered into 1 clonal complex (Figure 1, panel A), and 4 genotypes were singletons.
To investigate the utility of these primers in a clinical setting, we selected 10 formalin-fixed, paraffin-embedded specimens in which 2 clonal populations had been diagnosed by flow cytometry, morphology, or immunohistochemistry.
One study has shown a strong correlation between the degree of clonal diversity and the probability of invasive progression of Barrett esophagus to esophageal lesions, thus correlating heterogeneity with the development of malignancy [reviewed in (2)].
If we want to use PFGE for source tracking in a large watershed like the Santa Ana River, a very extensive DNA fingerprint library is needed, because our study shows that even a minor change in the DNA fingerprint can significantly affect clonal groupings," Ibekwe explains.
Researchers from the Smithsonian Tropical Research Institute and Scripps Institution of Oceanography report that hungry, sexual organisms replaced well-fed, clonal organisms in the Caribbean Sea as the Isthmus of Panama arose, separating the Caribbean from the Pacific.
In clonal seeds, the endosperm peak is further to the right because there is more DNA in each nucleus
Specific formulations will be provided for different aspects of passaging and clonal selection of mammalian ES cells.
The clonal nature of most malignant tumors is well established.
Paul, MN, announced in early May that its clonal stem cell lines defined by the company as Multi-Lineage Progenitor Cells (MLPCs) are commercially available.