clonal selection theory


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Related to clonal selection theory: clonal selection theory of immunity

clonal selection theory

[¦klōn·əl si′lek·shən ‚thē·ə·rē]
(immunology)
Theory to explain the specificity of the adaptive immune response according to which there is a large pool of lymphocytes, each having genetically predetermined specificity for only one of a vast array of possible antigens. Upon encountering an antigen, the lymphocytes sensitive to it reproduce much more rapidly than the others, thus leading to a build-up of antigen-specific cells large enough to mount the response.
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References in periodicals archive ?
Podolsky, The Generation of Diversity: Clonal Selection Theory and the Rise of Molecular Immunology (Cambridge, MA: Harvard University Press, 1997).
Other features of the approach were based on the clonal selection theory and other immunological mechanisms.
Coello Coello and Cruz-Cortes [7] have proposed an algorithm based on the clonal selection theory for solving constrained optimization problems.