clone

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clone,

group of organisms, all of which are descended from a single individual through asexual reproduction, as in a pure cell culture of bacteria. Except for changes in the hereditary material that come about by mutationmutation,
in biology, a sudden, random change in a gene, or unit of hereditary material, that can alter an inheritable characteristic. Most mutations are not beneficial, since any change in the delicate balance of an organism having a high level of adaptation to its environment
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, all members of a clone are genetically identical. In 1962 John GurdonGurdon, Sir John Bertrand,
1933–, British biologist, Ph.D. Oxford, 1962. He has been a researcher at Cambridge since 1971. Gurdon was the joint recipient of the 2012 Nobel Prize in Physiology or Medicine with Shinya Yamanaka for the discovery that mature cells can be
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 was the first to clone an animal when he transferred cell nuclei from adult frog intestinal cells and injected them into egg cells from which the nucleus had been removed; the eggs then developed into tadpoles. Laboratory experiments in in vitro fertilizationin vitro fertilization
(IVF), technique for conception of a human embryo outside the mother's body. Several ova, or eggs, are removed from the mother's body and placed in special laboratory culture dishes (Petri dishes); sperm from the father are then added, or in many cases a
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 of human eggs led in 1993 to the "cloning" of human embryos by dividing such fertilized eggs at a very early stage of development, but this technique actually produces a twin rather than a clone. In a true mammalian clone (as in Gurdon's frog clone) the nucleus from a body cell of an animal is inserted into an egg, which then develops into an individual that is genetically identical to the original animal.

Later experiments in cloning resulted in the development of a sheep from a cell of an adult ewe (in Scotland, in 1996), and since then rodents, cattle, swine, and other animals have also been cloned from adult animals. Despite these trumpeted successes, producing cloned mammals is enormously difficult, with most attempts ending in failure; cloning succeeds 4% or less of the time in the species that have been successfully cloned. In addition, some studies have indicated that cloned animals are less healthy than normally reproduced animals.

In 2001 researchers in Massachusetts announced that they were trying to clone humans in an attempt to extract stem cellsstem cells,
unspecialized human or animal cells that can produce mature specialized body cells and at the same time replicate themselves. Embryonic stem cells are derived from a blastocyst (the blastula typical of placental mammals; see embryo), which is very young embryo that
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. The National Academy of Sciences, while supporting (2001) such so-called therapeutic or research cloning, has opposed (2002) the cloning of humans for reproductive purposes, deeming it unsafe, but many ethicists, religious and political leaders, and others have called for banning human cloning for any purpose. South Korean scientists announced in 2004 that they had cloned 30 human embryos, but an investigation in 2005 determined that the data had been fabricated. In 2013 scientists at Oregon Health and Science Univ. reported that they had created embryonic stem cells using genetic material from human skin cells and donated eggs; the technique used to create the embryo, however, would not result in a viable human clone.

Bibliography

See G. Kolata, Clone (1997).

Clone

 

several successive generations of hereditarily similar organisms (or individual cells in cultures), formed as a result of asexual or vegetative reproduction from a common ancestor.

Isolating a clone is one of several ways of obtaining genotypically uniform material. However, because of possible mutations, the genotypic homogeneity of a clone is relative. The varieties of plants cultivated vegetatively (for example, the potato) are often individual clones.

In microbiology and protistology, a clone is the set of progeny of a single parental cell.

clone

[klōn]
(biology)
All individuals, considered collectively, produced asexually or by parthenogenesis from a single individual.
(computer science)
A hardware or software product that closely resembles another product created by a different manufacturer or developer, in operation, appearance, or both.
(genetics)
An organism whose diploid nuclear genome was derived from a somatic cell of another organism of the same species using biotechnologys.
A copy of a genetically engineered DNA sequence.

clone

One of a series of plants that is reproduced by cuttings or other vegetative methods for several generations.

clone

1. Biology a group of organisms or cells of the same genetic constitution that are descended from a common ancestor by asexual reproduction, as by cuttings, grafting, etc., in plants
2. a segment of DNA that has been isolated and replicated by laboratory manipulation: used to analyse genes and manufacture their products (proteins)

clone

(jargon)
1. An exact copy of a product, made legally or illegally, from documentation or by reverse engineering, and usually cheaper.

E.g. "PC clone": a PC-BUS/ISA, EISA, VESA, or PCI compatible x86-based microcomputer (this use is sometimes misspelled "klone" or "PClone"). These invariably have much more bang per buck than the IB PCM they resemble.

E.g. "Unix clone": An operating system designed to deliver a Unix-like environment without Unix licence fees or with additional "mission-critical" features such as support for real-time programming.

2. <chat> A clonebot.

clone

(1) To make an identical copy of something. See cloning software.

(2) A product that functions like another. The clone, which may be hardware, software or both, may not look exactly like the original, but it implies 100% functional compatibility with it. Fed the same input, the clone should produce the same output. See PC clone, white box and clean room technique.
References in periodicals archive ?
We used a gold standard multiplex PCR protocol provided by European Biomedicine and Health (BIOMED-2) Concerted Action Project BMH4-CT98-3936 for improvement of diagnosis and analysis of clonality gene rearrangement in lymphoma malignancies.
viridiflora in the north showed a degree of clonality (Table 1), higher than the levels of the sympatric P.
EuroClonality/BIOMED-2 guidelines for interpretation and reporting of Ig/TCR clonality testing in suspected lymphoproliferations.
Polymerase chain reaction (PCR) has been used to identify clonality, but its reliability often depends on the relative abundance of the cell popul ation in question and can be affected by sampling errors and large numbers of "contaminating" cells (Fend and Raffeld 2000; Orba et al.
This variant of HES also requires the absence of chromosomal evidence of clonality, in which case the diagnosis of chronic eosinophilic leukemia is more appropriate.
Patient and Tumor Systemic-NHL Primary CNS-NHL Characteristics Histology Large cell and Large cell small noncleaved cell Clonality Monoclonal or polyclonal Monoclonal EBV DNA in tumors Present in minority Almost always present Median CD4 cell count ~100 cells/[mm.
This test offers deep clonality assessment of blood and marrow samples across multiple immune receptors in a clinical setting and has a seven day turnaround time from blood collection to results.
Detection of B-cell clonality by showcasing the restricted expression of one of the two immunoglobulin light chains (kappa or lambda) provides valuable molecular information for the diagnosis of NHLs.
These isolates were further investigated by using pulsed-field gel electrophoresis (PFGE) and repetitive sequence-based PCR (rep-PCR) strain typing using the Diversilab system (bioMerieux, Melbourne, Victoria, Australia) to exclude clonality and delineate the possibility of a point source as the cause of these infections.
In situ hybridization for [kappa] and [lambda] messenger RNA (mRNA) demonstrated a mild [lambda] predominance, but the [kappa]: [lambda] ratio was insufficiently skewed for definitive determination of clonality.
They made a detailed molecular dissection of healthy and colon cancer tissue to address fundamental questions about tumor heterogeneity and clonality.