The WHO says hemophilia A is the most common form, referred to as classical hemophilia, which is the result of a deficiency in clotting factor
A: Hemophilia is a bleeding disorder in which blood has insufficient amount of certain proteins called blood clotting factors
that are needed for blood clotting or coagulation, i.
The slight reduction in clotting factor
XII activity (53 IU/dL; reference interval 70-150 IU/dL) was considered secondary.
The proteins in plasma include the major clotting factors
and intrinsic anticoagulants.
1,2) They report that early replacement of clotting factors
is critical--but often delayed--in managing patients with massive hemorrhage.
Treatment of chronic hepatitis C with ribavirin and interferon alfa-2b in patients with hemophilia appeared to reduce patients' use of clotting factors
in a small case series, reported Takashi Honda, M.
To manage the disorder, blood clotting factor
is infused (injected) to replace the missing protein.
Providers incur additional costs associated with delivering clotting factor
that are not separately reimbursed by Medicare.
About 3% to 4% of patients with hemophilia B, caused by a deficiency of clotting factor
IX, develop inhibitors in their blood that block the efficacy of factor IX replacement therapy administered to control bleeding episodes.
The genetic material included a human clotting factor
and a pig protein.
The five behaviors that qualified as high-risk were, for hemophiliacs, having received clotting factor
concentrations; for men, ever having had sex with another man since 1980; ever having taken street drugs by needle since 1980; ever having traded sex for money since 1980; and ever having had sex with a person who fits any of the above descriptions.
Gene delivery to the liver, where the factor IX clotting factor
is naturally produced, resulted in easily measurable levels of factor IX for the duration of the study (270 days) and no detectable antibodies or other inhibitors of factor IX.