Our reference interval compares well with previously published values obtained by methods using immunoprecipitation of HC and subsequent measurement of cobalamin
or vitamin [B.
In studies on tumor cell lines, the combination of cobalamin
and ascorbic acid produced hydrogen peroxide and had a synergistic effect in decreasing mitotic counts and survival of tumor cells.
For TSH, this may reflect gradual fine-tuning of homeostatic mechanisms, whereas for cobalamin
, it likely reflects gradual depletion of cobalamin
stores that were generated in utero.
2]O damages the protein by producing OH-radical, with depletion of cobalamin
being a secondary cause, NO should prevent only regeneration of the CH3-cbl(III) prosthetic group.
Inadequate release of protein-bound cobalamin
because of impaired gastric acid and pepsin secretion
12] group, all of the serum cobalamin
concentrations were obtained more than 24 hours after the last oral dose.
He cited the findings of a small study in which 18 geriatric patients with serum cobalamin
levels less than 150 pmol/L and cognitive dysfunction received intramuscular injections of 1,000 [micro]g of [B.
deficiency was diagnosed during hospitalization.
Access) is an emerging biopharmaceutical company focused on developing a range of products primarily based upon the company's three key drug delivery technologies: Synthetic Polymer Targeted Drug Delivery System, Cobalamin
Mediated Oral Drug Delivery System and Cobalamin
Mediated Targeted Drug Delivery System.
It is known that certain diseased cells, notably cancer, have an elevated demand for certain vitamins, including vitamin B12, making our Cobalamin
platform technology compelling for reformulations of cancer-killing agents nearing the end of their patent life," stated Jeffrey B.
Homocysteinemia(uria) may result from nutritional deficiency, cystathionine-[beta]-synthase mutations, or errors in folate and cobalamin
Objective: The imbalance between neurotoxic cytokine tumor necrosis factor-[alpha] (TNF-[alpha]) and neurotrophic cytokines epidermal growth factor (EGF) and interleukin-6 (IL-6) plays a role in the pathogenesis of cobalamin
(Cbl) deficiency-induced neuropathy.