cofactor


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cofactor

[′kō‚fak·tər]
(biochemistry)
A specific substance required for the activity of an enzyme, such as a coenzyme or metal ion.
(mathematics)
References in periodicals archive ?
CoFactor (ANX-510) is a folate-based biomodulator drug designed to enhance the activity and reduce associated toxicity of the widely used cancer chemotherapeutic agent 5-fluorouracil (5-FU).
Some studies have suggested HSV-2 is one such cofactor, and in vitro experiments have shown a synergistic interaction between HSV-2 and HPV, but the findings of the current study did not bear this out, Dr.
The identity and concentration of the divalent cation cofactor also affect rate.
PS binds to the [beta]-chain of C4b-BP with such affinity that all of the C4b-BP isoforms with a [alpha]-chain circulate as PS/C4b-BP complexes having no cofactor activity, whereas only ~0% of PS remains free.
Herpes simplex virus-2 as a human papillomavirus cofactor in the etiology of invasive cervical cancer, Journal of the National Cancer Institute, 2002, 94(21):1604-1613.
Carnitine supplementation is the best understood type of cofactor therapy.
Jon Armstrong, chief operating officer of Cofactor Genomics, commented, "Each of our respective companies has developed advanced genomic tools and services that, when combined, represent an unparalleled solution for moving from phenotype to genotype.
Among the materials and processes they consider are catalytic applications of laccase, the bacterial cytochrome P450 mono-oxygenases, preparing drug metabolites using fungal and bacterial strains, and recycling and substituting NAD(P)H as a CYP cofactor.
The monoclonal antibody may employ a cofactor and may be directed to a known substrate of an enzyme.
The function of a cofactor involved in biological catalysis is linked directly to its structure in vivo.
In reference to the quotes dispelling Judy Garland's death, viewing, and funeral as a cofactor in the Stonewall riots of June 1969 [From the Archives of The Advocate, February 27]: Riot witness Bob Kohler said that gay street youths who purportedly started the melee wouldn't have known who Judy Garland was or cared because they faced death every day.