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the best they could come up with was possible cogwheel rigidity for which they had no treatment or cure.
Table 18: Incidence of EPS Compared to Placebo in the Monotherapy Bipolar Depression Study LATUDA 20 to 60 80 to 120 Placebo mg/day mg/day (N=168) (N=164) (N=167) Adverse Event Term (%) (%) (%) All EPS events 5 12 20 All EPS events, excluding Akathisia/ 2 5 9 Restlessness Akathisia 2 8 11 Dystonia * 0 0 2 Parkinsonism ** 2 5 8 Restlessness <1 0 3 Note: Figures rounded to the nearest integer * Dystonia includes adverse event terms: dystonia, oculogyric crisis, oromandibular dystonia, tongue spasm, torticollis, and trismus ** Parkinsonism includes adverse event terms: bradykinesia, cogwheel rigidity, drooling, extrapyramidal disorder, glabellar reflex abnormal, hypokinesia, muscle rigidity, parkinsonism, psychomotor retardation, and tremor
On CNS examination, mask facies, reduced arm swinging, bradykinesia, tremors, cogwheel rigidity were elicited.
Parkinsonian features--including cogwheel rigidity, hypokinesia, and postural instability--were seen in 13 patients.