colchicine


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colchicine

(kŏl`chəsēn'), alkaloid extracted from plants of the genus Colchicum and especially from the corms of the autumn crocus, Colchicum autumnale (see meadow saffronmeadow saffron
or autumn crocus,
perennial garden ornamental (Colchicum autumnale) of the family Liliaceae (lily family). Native to Europe and N Africa, it has escaped from gardens to meadows and fields in some parts of the United States.
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). The metabolic effect of colchicine is not known, but it is thought that it may decrease production of lactic acid and prevent accumulation of uric acid crystals in the body, making it useful in the treatment of gout. Colchicine and derivatives such as demecolcine inhibit mitosismitosis
, process of nuclear division in a living cell by which the carriers of hereditary information, or the chromosomes, are exactly replicated and the two copies distributed to identical daughter nuclei.
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, or cell division. As a mitotic poison, it inhibits rapidly proliferating cells and has been used in cancer therapy and as an immunosuppressive drugimmunosuppressive drug,
any of a variety of substances used to prevent production of antibodies. They are commonly used to prevent rejection by a recipient's body of an organ transplanted from a donor.
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. Colchicine has also been used to visualize chromosomes photomicrographically and to induce mutations experimentally.

colchicine

[′käl·chə‚sēn]
(organic chemistry)
C22H25O6N An alkaloid extracted from the stem of the autumn crocus; used experimentally to inhibit spindle formation and delay centromere division, and medicinally in the treatment of gout.
References in periodicals archive ?
In an October 2010 letter published in the New England Journal of Medicine in response to an article about the colchicine debacle, FDA officials Janet Woodcock and Sarah Okada wrote:
Colchicine is therefore a successful treatment choice for EED.
Key words: Cellular, Colchicine, Immune, Nitric oxide, Macrophage.
Current guidelines in the United Kingdom suggest that an NSAID or low-dose colchicine can be considered equally for the first-line treatment of acute gout, Dr.
Earlier high dose colchicines therapy was used to treat acute attack of gout.
No significant difference was observed for the groups treated with colchicine and both extracts.
Most biological activities of colchicine are most likely associated with the formation of a tubulin-colchicine complex which interfering with microtubule assembly [4, 5].
First-line medical therapy includes aspirin or NSAIDs and colchicine.
In the past, diagnosis of FMF was based on clinical manifestations, ethnicity, family history, and response to colchicine treatment.