colchicine


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colchicine

(kŏl`chəsēn'), alkaloid extracted from plants of the genus Colchicum and especially from the corms of the autumn crocus, Colchicum autumnale (see meadow saffronmeadow saffron
or autumn crocus,
perennial garden ornamental (Colchicum autumnale) of the family Liliaceae (lily family). Native to Europe and N Africa, it has escaped from gardens to meadows and fields in some parts of the United States.
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). The metabolic effect of colchicine is not known, but it is thought that it may decrease production of lactic acid and prevent accumulation of uric acid crystals in the body, making it useful in the treatment of gout. Colchicine and derivatives such as demecolcine inhibit mitosismitosis
, process of nuclear division in a living cell by which the carriers of hereditary information, or the chromosomes, are exactly replicated and the two copies distributed to identical daughter nuclei.
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, or cell division. As a mitotic poison, it inhibits rapidly proliferating cells and has been used in cancer therapy and as an immunosuppressive drugimmunosuppressive drug,
any of a variety of substances used to prevent production of antibodies. They are commonly used to prevent rejection by a recipient's body of an organ transplanted from a donor.
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. Colchicine has also been used to visualize chromosomes photomicrographically and to induce mutations experimentally.

colchicine

[′käl·chə‚sēn]
(organic chemistry)
C22H25O6N An alkaloid extracted from the stem of the autumn crocus; used experimentally to inhibit spindle formation and delay centromere division, and medicinally in the treatment of gout.
References in periodicals archive ?
The acute attack can be very easily managed by using non-steroidal anti-inflammatory drugs (NSAIDs), colchicine or glucocorticosteroids, followed up by lifestyle modification and, if appropriate, urate-lowering therapy (ULT).
For technical reasons, few reports have been published measuring the value of colchicine levels in blood, its components (white blood cell), or urine (14).
Despite evidence of multiorgan disease, our patient experienced a complete and durable clinical remission on long-term low-dose prednisone and colchicine.
The present study was undertaken to observe the neuroprotective activity of alcoholic extract of MO leaves given orally on the brain monoaminergic systems in distinct brain regions in experimental model of Alzheimer is disease caused by intracerebroventricle (ICV) infusion of colchicine.
13,14) Some of these cases were thought to have FMF and were given colchicine.
Acemetacin, colchicine, and alendronic acid seem to be effective in the treatment of pachydermoperiostosis.
7% of patients given colchicine were diagnosed with incessant or recurrent pericarditis, while 37.
dose-reduction or avoidance of colchicine when the patient is taking cytochrome P450 3A4 or P-glycoprotein inhibitors, such as clarithromycin, various calcium-channel blockers, and so forth (12)).
For colchicine treatment selected concentrations were 50 and 100 [micro]g/ml and treatment duration was 4 to 8-hours.
Fatal poisoning in children: acute colchicine intoxication and new treatment approaches.
Major criteria were recurrent febrile episodes accompanied by peritonitis, synovitis, or pleuritic, Amyloidosis of AA-type without a predisposing disease and a favorable response to continuous Colchicine treatment.
Colchicine is an alkaloid used for the prophylaxis and treatment of gout.