colistin


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Related to colistin: Colistin sulfate

colistin

[kə′lis·tən]
(microbiology)
C45H85O10N13 A basic polypeptide antibiotic produced by Bacillus colistinus; consists of an A and B component, active against a broad spectrum of gram-positive microorganisms and some gram-negative microorganisms.
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Colistin is regarded as one of the last lines of defence against serious diseases, including pneumonia, which cannot be treated by other medicines.
Either international units or milligrams of the sodium salt colistimethate (the inactive prodrug) may be used, and to confuse matters further, colistin base activity (CBA) in milligrams may also be used to define the dose.
3 Interestingly, in this study, all strains were found sensitive to colistin, whereas up to 50% heteroresistance to colistin has been reported globally.
This poster demonstrates that plazomicin was associated with improved survival and a higher microbiological response rate compared with colistin in patients with bloodstream infections (BSI) caused by CRE.
among Gram-negative bacteria were isolated with a high rate, almost the only antibiotic that could be used for Acitenobacter strains was colistin, carbapenem resistance was considerably high in Pseudomonas strains and ESBL positivity was observed with a high rate in Enterobacteriaceae, especially E.
Colistin is not commonly used in clinical practice because of its neurotoxicity and nephrotoxicity, and this antibiotic has been considered as a therapeutic option for treatment of VAP caused by MDR NFGNB.
The following antibiotics were included: amoxicillin, amoxicillin-clavulanic acid (AMC), piperacillin, piperacillin-tazobactam (TZP), mezlocillin, mezlocillin-sulbactam (MSU), cefazolin, cefuroxime, ceftriaxone, cefotaxime, ceftazidime, cefoperazone, cefoperazone-sulbactam (CSL), cefepime, aztreonam, moxalactam, imipenem, meropenem, panipenem, ertapenem, gentamycin, amikacin, tetracycline, minocycline, tigecycline, ciprofloxacin, levofloxacin, nitrofurantoin, fosfomycin, polymyxin B, and colistin.
Over the last few year, scientists have found evidence that some bacteria have become resistant to a last resort antibiotic called colistin, Medical Daily reported.
The emerging issue of colistin resistance, due to the mobile plasmid-mediated lipid-A transferase gene mcr-1, was discussed by a number of presenters.