5,7,11-13) Agackiran et al (7) reported positive staining in 70% (7 of 10) of the mucinous tumors included in their study, including 4 of 4 colloid carcinomas
and 3 of 6 MAs, whereas Chu et al (13) reported 16 pulmonary MAs that were negative for napsin A.
60) The supposition is that once colloid carcinoma
cells overcome the protective barrier created by the mucin and infiltrate into the stroma as individual cells, they acquire (or reflect) an aggressive behavior that practically negates the survival advantage seen in pure colloid carcinomas
Because SPCs are commonly associated with invasive mucinous carcinoma, they were originally considered precursors of colloid carcinomas
Value of fine needle aspiration cytology of the breast, with an emphasis on the cytodiagnosis of colloid carcinoma
Several histologic variants of pancreatic cancer have been described, which include adenosquamous carcinoma, colloid carcinoma
, medullary carcinoma, signet ring cell carcinoma, undifferentiated carcinoma, and undifferentiated carcinoma with osteoclast-like giant cells.
There were 5 (11%) "good" prognosis subtypes of invasive carcinoma, including tubular/cribriform carcinoma (Figure, D), colloid carcinoma
(Figure, E), and papillary-cystic carcinoma.
In the most recent WHO classification published in 2004, (17) pulmonary adenocarcinomas were divided into acinar, papillary, bronchioloalveolar, solid adenocarcinoma with mucin production, and mixed subtypes, as well as several variants (fetal adenocarcinoma, mucinous or colloid carcinoma
, mucinous cystadenocarcinoma, signet ring adenocarcinoma, and clear cell carcinoma).
3,16,23,52,53) Lastly, colloid carcinoma
is another example of metastatic adenocarcinoma with unique histologic features that suggest a particular differential diagnosis of primary site.