colon cancer

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colon cancer,

cancer of any part of the colon (often called the large intestineintestine,
muscular hoselike portion of the gastrointestinal tract extending from the lower end of the stomach (pylorus) to the anal opening. In humans this fairly narrow (about 1 in./2.
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). Colon cancer is the second most common cancer diagnosed in the United States. Epidemiological evidence has shown that a diet high in fat and low in fruits, vegetables, and fiber contributes to the development of the disease. Smoking is also a factor in some types of colon cancer. Statistically, a family history of colon cancer or cancer of the female reproductive organs, a history of colon polyps, or a history of ulcerative colitis puts one at a greater risk of developing colon cancer. Colon cancer is most common in people over age 50.

Several genes that signal a hereditary predisposition to colon cancer have been identified. For example, mutations in either of two genes, MSH2 and MLH1, can predispose a person to hereditary nonpolyposis colorectal cancer (HNPCC). People in HNPCC families can undergo blood tests that can tell them whether they have an affected gene. With the information obtained from such screening, an appropriate course of preventive measures and follow-up tests can be initiated (see genetic testinggenetic testing,
medical screening for genetic disorders, by examining either a person's DNA directly or a person's biochemistry or chromosomes for indirect evidence. Testing may be done to identify a genetic disorder a person has, whether the disorder is already evident or not,
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A sudden change in bowel habits or blood in the feces (often detectable only in a laboratory) may be the first symptoms of colon cancer. In the early stages of the disease there may be no obvious symptoms. Diagnosis is made by physical examination of the rectum and a laboratory examination of blood for carcinoembryonic antigen (CEA), a tumor marker produced by colon cancers. These may be followed by an endoscopic examination of the colon with a sigmoidoscope (to examine the rectum and the adjoining sigmoid colon) or colonoscope (to examine the entire colon). A biopsybiopsy
, examination of cells or tissues removed from a living organism. Excised material may be studied in order to diagnose disease or to confirm findings of normality. Preparatory techniques depend on the nature of the tissue and the kind of study intended.
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 of any suspicious tissue, such as a polyp or a flat or depressed lesion, is then examined in a laboratory to determine if cancerous changes are present. If cancer is found, the patient is evaluated to determine the extent of the primary tumor and whether the disease has spread throughout the body.


Treatment depends upon the stage of the cancer. The initial treatment is usually local excision of the tumor or excision of a larger part of the colon followed by the joining of the two adjacent ends, a procedure referred to as end-to-end anastomosis. In some cases a colostomy (an opening that allows waste to be expelled through an opening in the abdomen rather than through the anus) is created either temporarily, to allow healing, or permanently, if significant portions of the colon have had to be removed. If the disease is advanced, radiation therapy, chemotherapy, or biological therapies (therapies that stimulate the body's own immune defenses against the disease) may be used in addition to surgery.


See publications of the National Cancer Institute, the American Cancer Society, and the United Ostomy Association.

References in periodicals archive ?
Many of the issues for colon cancer screening arise from fear of colonoscopy - fear of the risks of the procedure, fear of the procedure itself and fear of what the procedure will find.
According to the researchers, approximately two-thirds of patients with colon cancer carry such bacteria, compared with one in five with a healthy colon.
The key next step will be to determine whether we can use VELs for 'personalized medicine,' to molecularly define distinct groups of colon cancers that differ in their clinical behavior, and to enable selection of specific drugs that will best treat a given colon tumor.
If the level of N-nitroso compounds was an important cause of colon cancer, "the drop in N-nitroso compound content caused by the mandated changes in processed meat should have been accompanied by a drop in the incidence of colon cancer," said Mirvish.
For every HIV-infected person who met these requirements, the researchers signed up 2 people without HIV who had come for a colonoscopy without symptoms of colon cancer.
PHILADELPHIA -- Nearly 40% of women over age 50 have never received a recommendation from their doctors to be screened for colon cancer, according to survey results presented at the annual meeting of the American College of Obstetricians and Gynecologists.
The purpose of Dress in Blue Day is to promote awareness about colon cancer, one of the few cancers you can prevent by getting screened early," said Andrew Spiegel, CEO of the Colon Cancer Alliance (CCA).
WHY: Approximately 150,000 people will be diagnosed with colon cancer this year, and almost 60,000 will die.
22, 2013 /PRNewswire/ -- The Colon Cancer Challenge Foundation(CCCF), a New York-based nonprofit dedicated to reducing colorectal cancer incidence and death throughout the United States, has given the Colon Cancer Challenge Foundation/CGA-ICC Colorectal Cancer Research Scholar Award to Deborah Cragun.
His own data show that citrus limonoids protect against chemically induced colon cancer in lab animals.
The Colon Cancer Prevention Project's mission is to eliminate preventable colon cancer death and suffering by increasing screening rates through education, advocacy, health systems improvement and survivor support.