column bleed

column bleed

[′käl·əm ‚blēd]
(analytical chemistry)
The loss of carrier liquid during gas chromatography due to evaporation into the gas under analysis.
References in periodicals archive ?
The small internal diameter and thinner film reduce the column bleed that can interfere with quantification of the higher molecular weight PAHs.
Using purifiers with indicators, and remembering to check them regularly, helps minimize GC column bleed and extend column lifetimes while improving system sensitivity.
Column bleed is the loss of lower molecular weight stationary phase pieces that are either the result of impurities in the starting polymer or the decomposition of the phase at elevated temperatures.
The company claims it uses a proprietary bonding and deactivation procedure that lowers column bleed and reduces activity.
Bowers and Borts argue that the lack of improvement for the QIT when presented with an analyte present in a complex matrix arises because the width of the window for ion admittance to the trap allows matrix or column bleed ions (or both) to enter with the analyte ions.
The columns are compatible with highly aqueous mobile phase and feature low column bleed, high efficiency and rugged packing.
In this instance, the oven must be cooled at a much slower rate to allow dissipation of the column bleed so that 'focused' condensation within the column does not occur.
Thus, the ratio of the number of ions from column bleed or matrix background to the number of ions of the compound of interest stays the same at the time that the total analytical signal is decreased.
If the carrier gas contains even trace amounts of water or oxygen it may damage the GC column stationary phase, resulting in bad peak shape and excessive column bleed.
Advantages of fast GC include reduced run times, increased sample throughput, improved signal-to-noise ratio and less column bleed (thinner films).
Reduced column bleed minimizes the risk of contamination of the mass spectrometer while extending the interval between scheduled maintenance.
The low column bleed provides increased detector sensitivity and faster baseline stabilization.