chemotherapy

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Related to combination chemotherapy: antitumor, Chemotherapeutic agent

chemotherapy

(kē'mōthĕr`əpē), treatment of disease with chemicals or drugsdrugs,
substances used in medicine either externally or internally for curing, alleviating, or preventing a disease or deficiency. At the turn of the century only a few medically effective substances were widely used scientifically, among them ether, morphine, digitalis,
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. One chemotherapeutic approach is the development of selectively toxic substances, i.e., substances that can destroy or inhibit infecting organisms or, as in cancer, malignant tissue, but do not damage normal host tissue. In treating infection, selectively toxic agents may block a biochemical reaction necessary to the viability of the pathogen but not to that of the host; for example, penicillinpenicillin,
any of a group of chemically similar substances obtained from molds of the genus Penicillium that were the first antibiotic agents to be used successfully in the treatment of bacterial infections in humans.
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 blocks synthesis of bacterial cell walls, a component animal cells lack. Other chemotherapeutic substances differentially affect biochemical reactions in different tissues; thus antimetabolites such as methotrexate and CytoxanCytoxan
, trade name for the drug cyclophosphamide, used to inhibit growth of tumors and rapidly proliferating cells. It is used in the treatment of leukemia, Hodgkin's disease, and lymphosarcoma and other solid tumors.
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 are more toxic to rapidly proliferating cells such as those associated with cancer than to normal cells. Other drugs act in various ways to produce effects that initiate or enhance some normal body function; for instance, neostigmine blocks the action of an enzyme limiting transmission of nerve impulses and thereby acts as a nervous system stimulant. The usefulness of chemotherapeutic agents also depends on their pharmacological action, e.g., their rate of absorption, rapidity of action and rate of excretion, degree of storage in the body, effects of products of their metabolic breakdown, and potential for causing hypersensitivityhypersensitivity,
heightened response in a body tissue to an antigen or foreign substance. The body normally responds to an antigen by producing specific antibodies against it. The antibodies impart immunity for any later exposure to that antigen.
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 reactions. Some drugs are given prophylactically, to prevent infection, e.g., penicillin is given to rheumatic fever patients to prevent reinfection by the causative organism, the streptococcal bacterium.

Chemotherapy

 

the use of drugs to act on the causative agents of infectious and parasitic diseases and on tumor cells. The treatment of disease by chemical agents was first practiced early in the 20th century, after P. Ehrlich demonstrated the directed synthesis of agents capable of acting on microorganisms. Ehrlich used salvarsan (the first potent agent in chemotherapy) in 1909 and established the principal mechanisms of the specific action of chemical agents.

REFERENCES

Ehrlich, P. Materialy k ucheniiu o khimioterapii. St. Petersburg, 1911. (Translated from German.)
Khimioterapiia infektsionnykh boleznei (collection of articles). Moscow, 1958.
Strategiia khimioterapii. Moscow, 1960. (Translated from English.)
Larionov, L. F. Khimioterapiia zlokachestvennykh opukholei. Moscow, 1962.
Votchal, B. E. Ocherki klinicheskoi farmakologii, 2nd ed. Moscow, 1965.
Kassirskii, I. A., and Iu. L. Milevskaia. Ocherki sovremennoi klinicheskoi terapii, 2nd ed. Tashkent, 1970.

chemotherapy

[‚kē·mō′ther·ə·pē]
(medicine)
Administering chemical substances for treatment of disease, especially cancer and diseases caused by parasites.

chemotherapy

treatment of disease, esp cancer, by means of chemical agents
References in periodicals archive ?
A single institution experience of 30 cases in the combination chemotherapy era.
17 months) The median duration of combination chemotherapy was 4.
Our study compared referral and treatment rates of neoadjuvant chemotherapy for patients with muscle-invasive bladder cancer before and after publication of a CPG recommending cisplatin-based combination chemotherapy.
Instances of DVT triggered by thalidomide have been reported in the induction phase of combination chemotherapy especially with doxorubicin and cyclophosphamide in patients with multiple myeloma and other malignancies.
Also, the difference in toxicity profile between the 2 agents makes the combination a good candidate for an effective and well-tolerated combination chemotherapy regimen.
Patients over 60 were also less likely to be offered combination chemotherapy than younger ones.
2) Combination chemotherapy with pyrimethamine increased from <20% of all treatment courses on plantation 1 in 1998 to 85% of all treatment courses by 2001.
For nonresponders, a combination chemotherapy can be tried.
In other controlled research, conducted mostly on women with breast cancer, combination chemotherapy with methotrexate, cyclophosphamide, and 5-fluorouracil has been most frequently associated with cognitive problems, although neurotoxicity has also been reported with other commonly used cancer drugs.
The patients received 2, 4 or 6 cycles of combination chemotherapy.
The treatment with total nodal irradiation and subsequent four-drug combination chemotherapy under a protocol was begun.
Combination chemotherapy of metastatic malignant schwannoma with vincristine, adriamycin, cyclophosphamide, and imidazole carboxamide: A case report.