complement cascade


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Related to complement cascade: Membrane attack complex

complement cascade

[′käm·plə·mənt kas′kād]
(immunology)
The sequential activation of complement proteins resulting in lysis of a target cell.
References in periodicals archive ?
28 C3 and C5 are the key element of the complement cascade activation system and markers.
The novel antibody targets a component of the complement cascade with therapeutic potential in both orphan and large market indications like Ischemia/Reperfusion Injuries (IRI)".
She and her colleagues recently implicated a different complement cascade protein in schizophrenia (SN: 2/20/16, p.
In targeting the Complement cascade in the innate immune system, iPicrian's platform is being leveraged to tease out specific mechanisms of chronic inflammation that occur in various brain disorders.
Genes over-expressed in the RPE-choroid - a tissue complex located beneath the retina - included components of inflammatory responses, while in the retina, the researchers found genes involved in wound healing and the complement cascade, a part of the innate immune system.
The complement cascade plays a key role in the modulation of inflammatory responses and its activation has been reported to be crucial to the pathogenesis of various diseases (5).
The major target of the active C3bBb is C3 itself, resulting in rapid amplification of the complement cascade.
Research suggests that levels of chemicals involved in the complement cascade are 100 times higher than normal in people with AD.
The ultimate fate of this complement cascade is often pathogen destruction by direct cell rupture ("lysis") or, more often, through the induction of cytokine release and the recruitment of other cells that destroy the pathogen through phagocytosis (Abbas, 2005).
The complement cascade has been implicated in the destruction of red blood cells, or hemolysis, characteristic of PNH, as PNH blood cells are deficient in natural inhibitors of the complement cascade.
One hundred and seventy-eight ethanolic plant extracts from the pharmacopoeia of the Tacana, an ethnic group from Bolivia, were screened for immunomodulatory activity using complement cascade inhibition and ADP-induced platelet aggregation inhibition assays.
CHICAGO -- Selective inhibition of the complement cascade for 24 hours markedly reduced mortality after acute MI in a large phase II clinical trial.
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