Also found in: Dictionary, Thesaurus, Medical, Legal, Wikipedia.
Related to conformation: confirmation


a. another name for configuration
b. one of the configurations of a molecule that can easily change its shape and can consequently exist in equilibrium with molecules of different configuration



(of molecules), geometric forms that molecules of organic compounds can assume during the rotation of atoms or groups of atoms (substituents) about single bonds while maintaining the order of the chemical bonding of the atoms (chemical structures), the bond lengths, and valency angles. Molecules that differ from one another only in conformation are called conformers, or rotational isomers. The existence of conformations is determined by the spatial interaction (such as repulsion, attraction, and hydrogen bond formation) of substituents (hydrogen atoms included) that are not bonded to one another. One such example (see Figure 1) is represented by several planar conformations of a pentane molecule:


Unlike geometric and optical isomers, conformers under general conditions easily convert into one another (without the breaking of bonds) and therefore cannot be isolated (compareCONFIGURATION). The molecules of organic compounds usually exist in the form of a mixture of conformers that are in equilibrium,

Figure 1. Planar conformations of a pentane molecule: (a) zigzag, (b) claw-shaped, (c) irregular

among which those that are energetically most favorable, that is, exhibiting the lowest energy, predominate. The conformational state of molecules affects the physical properties of substances and the orientation and rate of chemical transformations (see).



(organic chemistry)
In a molecule, a specific orientation of the atoms that varies from other possible orientations by rotation or rotations about single bonds; generally in mobile equilibrium with other conformations of the same structure. Also known as conformational isomer; conformer.
References in periodicals archive ?
Genetic parameters of linear scored conformation traits and their relation to dressage and show-jumping performance in the Dutch Warmblood Riding Horse population.
The conformation tensor is very well adapted to describe the flow of polymeric fluids and it is able to specify the deformation of polymeric chains during the flow [17, 18].
Hastings has taken the conformation evaluation procedure used to judge show dogs for appearance and adapted it to judge the practical significance of conformation in sport dogs--gun dogs in particular.
About the DAC Blockers Discovery Platform Compugen's Blockers of Disease-Associated Conformation (DAC Blockers) platform was first disclosed in March 2008, and is one of ten product candidate discovery platforms validated to date by the company.
We tried to make this into a conformation class and it obviously was well received.
Through this technique, improved efficiency of various experiments starting with conformation analysis of proteins and X ray crystallography and NMR will be possible.
Good conformation of the dry film resist to the base material during lamination is vital if the fabricator is to achieve high yields.
An important consideration was udder conformation, as many of the small breeds do not have good conformation and present a difficulty in milking.
Protocols for inserting membrane proteins in this, the most promising membrane support system identified so far, are currently being developed to enable SANS measurements of the conformation the proteins have in actual cell membranes.
Sections stained with Congo red dye demonstrated the characteristic yellow and apple-green birefringence, and the lesion had the beta-pleated sheet structure and antiparallel conformation by low-angle x-ray diffraction, typical of amyloidosis.
Recent developments include conformation of all escuela work to the Pericets' legacy; full Spanish translations; and a parallel all-flamenco syllabus with contratiempo (counter-rhythm), bulerias (a rhythmically complex, extroverted flamenco genre), and other focused flamenco work replacing the escuela and regional sections.
The ability to access clean data is an enormous advantage for the user, since errors in identification, classification, spelling, and vocabulary conformation can severely hinder the discovery process," stated Richard Resnick, NetGenics director of Database Development.