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Related to conformation: confirmation


a. another name for configuration
b. one of the configurations of a molecule that can easily change its shape and can consequently exist in equilibrium with molecules of different configuration



(of molecules), geometric forms that molecules of organic compounds can assume during the rotation of atoms or groups of atoms (substituents) about single bonds while maintaining the order of the chemical bonding of the atoms (chemical structures), the bond lengths, and valency angles. Molecules that differ from one another only in conformation are called conformers, or rotational isomers. The existence of conformations is determined by the spatial interaction (such as repulsion, attraction, and hydrogen bond formation) of substituents (hydrogen atoms included) that are not bonded to one another. One such example (see Figure 1) is represented by several planar conformations of a pentane molecule:


Unlike geometric and optical isomers, conformers under general conditions easily convert into one another (without the breaking of bonds) and therefore cannot be isolated (compareCONFIGURATION). The molecules of organic compounds usually exist in the form of a mixture of conformers that are in equilibrium,

Figure 1. Planar conformations of a pentane molecule: (a) zigzag, (b) claw-shaped, (c) irregular

among which those that are energetically most favorable, that is, exhibiting the lowest energy, predominate. The conformational state of molecules affects the physical properties of substances and the orientation and rate of chemical transformations (see).



(organic chemistry)
In a molecule, a specific orientation of the atoms that varies from other possible orientations by rotation or rotations about single bonds; generally in mobile equilibrium with other conformations of the same structure. Also known as conformational isomer; conformer.
References in periodicals archive ?
Scores for conformation (C), finishing precocity (P), and musculature (M) scores (1-5 range) were individually assigned to each animal, being related to the management group, and the highest notes indicate a stronger presence of the characteristic, as described by SEVERO (1994).
16] indicated that feeding treatments/management systems had low effect on body compactness and conformation.
Stark was 6 months old when Estolano first entered him in a conformation show.
Heritability of foot conformation and its relationship to sports performance in a Dutch Warmblood horse population.
This is a Leonov-like model in which the determinant of conformation tensor must remain constant.
Body conformation and linear type traits are very important because they are correlated with performance of dairy animals.
To show the impact of protein conformation, fluorescence spectra were measured for the proteins diluted in phosphate-buffered saline (1X PBS pH 7.
The team earlier succeeded in generating a three dimensional conformation that is unique to pancreatic islets, but it required a longer time to create and the conformation could not produce sufficient insulin.
com)-- GBI Research, a leading business intelligence provider, has released its latest research, Offshore Rig Construction Market to 2016 and Current Rig Deployment Scenario Rig Designs Promoting Better Safety Conformation and Increased Operational Capabilities being Key to Newbuild Orders.
Tamiflu binds weakly with the open conformation due to poor electrostatic interactions between the drug and the active site, thus rendering the drug ineffective," Professor Mulholland added.