conformation

(redirected from conformational)
Also found in: Dictionary, Thesaurus, Medical, Legal, Wikipedia.
Related to conformational: Conformational analysis, conformational epitope

conformation

Chem
a. another name for configuration
b. one of the configurations of a molecule that can easily change its shape and can consequently exist in equilibrium with molecules of different configuration

Conformation

 

(of molecules), geometric forms that molecules of organic compounds can assume during the rotation of atoms or groups of atoms (substituents) about single bonds while maintaining the order of the chemical bonding of the atoms (chemical structures), the bond lengths, and valency angles. Molecules that differ from one another only in conformation are called conformers, or rotational isomers. The existence of conformations is determined by the spatial interaction (such as repulsion, attraction, and hydrogen bond formation) of substituents (hydrogen atoms included) that are not bonded to one another. One such example (see Figure 1) is represented by several planar conformations of a pentane molecule:

CH3—CH2—CH2—CH2—CH3

Unlike geometric and optical isomers, conformers under general conditions easily convert into one another (without the breaking of bonds) and therefore cannot be isolated (compareCONFIGURATION). The molecules of organic compounds usually exist in the form of a mixture of conformers that are in equilibrium,

Figure 1. Planar conformations of a pentane molecule: (a) zigzag, (b) claw-shaped, (c) irregular

among which those that are energetically most favorable, that is, exhibiting the lowest energy, predominate. The conformational state of molecules affects the physical properties of substances and the orientation and rate of chemical transformations (see).

V. M. POTAPOV

conformation

[kän·fər′mā·shən]
(organic chemistry)
In a molecule, a specific orientation of the atoms that varies from other possible orientations by rotation or rotations about single bonds; generally in mobile equilibrium with other conformations of the same structure. Also known as conformational isomer; conformer.
References in periodicals archive ?
Sc] conformational (and possibly strain) variants in CH1641-like isolates.
The binding of NT1 to mAb M3 was abolished by heat treatment, indicating that mAb M3 reacted with continuous or discontinuous conformational determinants.
The results demonstrated that when the specific antigens were introduced, a conformational change of the antibody occurred, increasing the distance between the dyes.
At the [beta]Ala93 site, water molecules did not replace the cysteine side chain, and the alanine substitution increased the conformational freedom of [beta]His146, weakening the important interaction of this residue with [beta]Asp94.
When this thermoset formed from the thermoset precursors which had dissolved into amorphous PVC, both PVC and thermoset polymer segments interact with one another causing extensive conformational redistributions within the SIPN domain.
In the current study, we provide a theoretical analysis using a FEM of the heart to explore the feasibility that a microgravity environment might generate conformational changes in the heart.
Biodesy has developed a unique and highly sensitive technology for detecting conformational change in proteins and other biological molecules.
We expected that this methyl-handoff between B vitamins must involve some type of conformational change, but the dramatic rearrangements that we have observed surprised even us," Senior author Catherine L.
Conformational transition of SF from random coil to [beta]-sheet form can perform by heat treatment, alcohol treatment, polymer blending and cross-linking [7-9].
In the high-frequency region, modeling of the dough matrix reveals a structural relaxation in the nanosecond time range that is likely associated with conformational changes in gluten proteins.
of California at Santa Barbara) to propose the DHA principle, which "states that the blending of lipids to form cellular membranes is evolutionarily honed to maximize benefit while minimizing risk, and that a complex blending code involving conformational dynamics, energy stress, energy yield, and chemical stability underlies all cellular membranes.
By manipulating light, Virun has been able to avoid chemical conformational changes of the fatty acids without having to use preservatives.