conformation

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conformation

Chem
a. another name for configuration
b. one of the configurations of a molecule that can easily change its shape and can consequently exist in equilibrium with molecules of different configuration

Conformation

 

(of molecules), geometric forms that molecules of organic compounds can assume during the rotation of atoms or groups of atoms (substituents) about single bonds while maintaining the order of the chemical bonding of the atoms (chemical structures), the bond lengths, and valency angles. Molecules that differ from one another only in conformation are called conformers, or rotational isomers. The existence of conformations is determined by the spatial interaction (such as repulsion, attraction, and hydrogen bond formation) of substituents (hydrogen atoms included) that are not bonded to one another. One such example (see Figure 1) is represented by several planar conformations of a pentane molecule:

CH3—CH2—CH2—CH2—CH3

Unlike geometric and optical isomers, conformers under general conditions easily convert into one another (without the breaking of bonds) and therefore cannot be isolated (compareCONFIGURATION). The molecules of organic compounds usually exist in the form of a mixture of conformers that are in equilibrium,

Figure 1. Planar conformations of a pentane molecule: (a) zigzag, (b) claw-shaped, (c) irregular

among which those that are energetically most favorable, that is, exhibiting the lowest energy, predominate. The conformational state of molecules affects the physical properties of substances and the orientation and rate of chemical transformations (see).

V. M. POTAPOV

conformation

[kän·fər′mā·shən]
(organic chemistry)
In a molecule, a specific orientation of the atoms that varies from other possible orientations by rotation or rotations about single bonds; generally in mobile equilibrium with other conformations of the same structure. Also known as conformational isomer; conformer.
References in periodicals archive ?
3][gamma] crystal structure, (10) and the binding of MgADP induced a conformational change from the open to the closed form (a bending motion) in T[F.
Sc] from sheep prion isolates by CSSA showed an extremely high conformational stability of BSE samples, we improved the Istituto Superiore di Sanita discriminatory WB by including a pretreatment of brain homogenates with GdnHCl.
We used heat denaturation of the fusion proteins tethered to the EBY100 yeast cell surface to categorize the specific linear and conformational SARS-CoV N protein mAb epitopes (35, 36).
At the [beta]Ala93 site, water molecules did not replace the cysteine side chain, and the alanine substitution increased the conformational freedom of [beta]His146, weakening the important interaction of this residue with [beta]Asp94.
It can either be utilized, as in polymer synthesis, or be dissipated as heat, making the conformational change nearly irreversible.
This leads to a different crystallization throughout the whole volume and consequently to conformational changes that could be followed by means of spectroscopic techniques.
To understand how individual protein molecules respond to thermal noise, we have studied dynamic changes of the conformational state of proteins using single molecule imaging.
Conformational change upon binding of the substrate as detected by HDX-MS is consistent with what was observed in crystal structures.
They cover novel applications of traditional biophysical techniques; emerging technologies and their applications; biophysical applications relevant to state-wise development of a clinical biotherapeutic candidate; and some of the thermodynamic, conformational, and stabilization concepts aided by biophysical research.
13,17,18) If microgravity exposure primarily induces alterations in local ventricular geometry and wall stress through conformational changes in the overall shape of the heart, then a general remodeling of myocardium might also occur.
He covers the essence of fluid mechanics, conformational transformation, the transformation of a flow pattern, vortex theory, thin aerofoil theory, the panel method, finite aerofoil theory, compressible flows, and sample flights.
He adds that the technique could be applied not only to protein folding intermediates, but any conformational change in proteins including allosteric transitions and macromolecular assembly.