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a. another name for configuration
b. one of the configurations of a molecule that can easily change its shape and can consequently exist in equilibrium with molecules of different configuration



(of molecules), geometric forms that molecules of organic compounds can assume during the rotation of atoms or groups of atoms (substituents) about single bonds while maintaining the order of the chemical bonding of the atoms (chemical structures), the bond lengths, and valency angles. Molecules that differ from one another only in conformation are called conformers, or rotational isomers. The existence of conformations is determined by the spatial interaction (such as repulsion, attraction, and hydrogen bond formation) of substituents (hydrogen atoms included) that are not bonded to one another. One such example (see Figure 1) is represented by several planar conformations of a pentane molecule:


Unlike geometric and optical isomers, conformers under general conditions easily convert into one another (without the breaking of bonds) and therefore cannot be isolated (compareCONFIGURATION). The molecules of organic compounds usually exist in the form of a mixture of conformers that are in equilibrium,

Figure 1. Planar conformations of a pentane molecule: (a) zigzag, (b) claw-shaped, (c) irregular

among which those that are energetically most favorable, that is, exhibiting the lowest energy, predominate. The conformational state of molecules affects the physical properties of substances and the orientation and rate of chemical transformations (see).



(organic chemistry)
In a molecule, a specific orientation of the atoms that varies from other possible orientations by rotation or rotations about single bonds; generally in mobile equilibrium with other conformations of the same structure. Also known as conformational isomer; conformer.
References in periodicals archive ?
Inhibition and substrate activity of conformationally rigid vigabatrin analogues with [gamma]-aminobutyric acid aminotransferase.
The compounds studied are selected from two main areas of our research; the study of hydrogen-bond networks and polymorphism, and consist of single and multi-component systems containing both rigid and conformationally flexible molecules.
We proposed the preparation of a novel and diverse library of conformationally constrained peptidomimetics containing quaternary stereocenters derived from B/C/P approach with increased biological relevance.
RuiYi has developed a series of technologies, termed intermembranous Conformation Antigen Presenting System or iCAPS, that enable the presentation of purified, isolated, functional and conformationally correct GPCRs optimized for generation of antibodies and other biologic modulators.
Conformationally selective binding of nucleotide analogues to Escherichia coli RecA: a ligand-based analysis of the RecA ATP binding site.
Recent advances in ligand-based drug design: Relevance and utility of the conformationally sampled pharmacophore approach.
In separate studies, independent laboratory analysis has revealed that OXiGENE's Neu-Sensamide is a conformationally altered and thus a new proprietary formulation of metoclopramide.
The improved LJP chemistry process will facilitate the broad development of peptides that are more conformationally stable (able to hold their shape), more biologically active and less susceptible to biological degradation.
Nordenvall also revealed previously undisclosed information from the results of a Phase I trial of Neu-Sensamide(TM), a conformationally altered form of Sensamide(TM) being developed as a radio/chemosensitizer and an antiemetic.
patent #5,827,821 provides novel synthetic peptides, which incorporate the sequence RGD in conformationally stabilized forms that can target and control cell behavior.
They will work together to port FlexX(TM), FlexX-Pharm(TM) and FlexE(TM), programs that allow virtual screening of compound databases by rapidly docking flexible ligands at active sites, and Unity(R) 3D software that provides fast, conformationally flexible 3-D searching of chemical databases to United Devices' Grid MP(TM) platform.