connexins


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connexins

[kə′nek·sənz]
(cell and molecular biology)
A group of transmembrane proteins that form the intermembrane channels of gap junctions; they are used by inorganic ions and most small organic molecules to pass through cell interiors.
References in periodicals archive ?
This is because the presence of connexins suppresses primary tumor growth," Dr.
Each gap junction channel is formed by docking of two 'hemichannels', each containing six connexins, contributed by each neighboring cell.
Connexins form intercellular channels by combining in groups of six to form a structure called a connexon.
Pierre et Marie Curie, Paris; AP-HP Hopital Charles Foix, Centre de Recherche et Developpement, Ivry-sur-Seine, France) introduces types of gap junctions, their structural aspects, expression patterns of connexins (transmembrane proteins), and gap junction-related diseases due to mutations in connexin genes.
In unpublished work, she says she and her colleagues have shown that neurospheres express certain connexins, the molecules that form the gap junctions that mediate intercellular communication.
Specific topics include cadherins and connexins in pulmonary endothelial function, pulmonary endothelial progenitor cells, oxidant-mediated signaling and injury in pulmonary endothelium, therapeutic strategies to limit pulmonary endothelial cell permeability, genetic insights into endothelial barrier regulation in the acutely inflamed lung, and collagen vascular diseases and pulmonary endothelium.
The potassium ions then diffuse to the stria vascularis through gap junctions formed by connexins and are secreted back into the endolymph through potassium channel (9).
The exception to this situation is the so-called electrical synapse, in which ion-conducting pores made from proteins called connexins connect the intracellular compartments of adjacent neurons, allowing direct ion flow from cell to cell (Kandel et al.
A dose dependent decrease in protein levels was observed in connexins 32 and 43 for IMR-90.
Angiotensin-2 has been implicated in myocardial structural alterations that would be predicted to promote AF, including increased fibrosis and a marked reduction in connexins, Dr.