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conservative substitution

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conservative substitution [kən′sər·vəd·iv ‚səb·stə′tü·shən]
(cell and molecular biology)
Replacement of an amino acid in a polypeptide by one with similar characteristics.


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Thus, it was not surprising that we observed a high degree of protein homology between humans and chimpanzees in hNP and hGSTO1-1, with only one amino acid difference between human and chimpanzee hGSTO1-1, a conservative substitution of isoleucine (human) for valine (chimp) at residue 26.
 
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