The presence of continuous or recurrent constitutional symptoms
and the duration of acute illness were not correlated.
For myelofibrosis patients in general, clinical findings such as splenomegaly, anemia and constitutional symptoms
may significantly reduce quality of life10,11,12.
12, 2011, Location: Room 6B (San Diego Convention Center) Results of a Phase 2 Study of Pacritinib (SB1518), a Novel Oral JAK2 Inhibitor, In Patients with Primary, Post-Polycythemia Vera, and Post-Essential Thrombocythemia Myelofibrosis Pacritinib showed promising efficacy in alleviating MF-associated splenomegaly and constitutional symptoms
at a dose that induces minimal myelosuppression.
Except for the historical information contained herein, the matters set forth in this press release, including statements with respect to the ongoing clinical experience with INCB18424 and the dosing regimen for the Phase III program which has the potential to be well tolerated and provide durable clinical improvement in splenomegaly and constitutional symptoms
, plans to describe the most current data from the ongoing Phase II clinical trials of INCB18424 in myelofibrosis, PV and ET and AML at ASH, are all forward-looking statements within the meaning of the "safe harbor" provisions of the Private Securities Litigation Reform Act of 1995.
Tuberculosis does result in more constitutional symptoms
, but they are not specific.
On history, he denied hematuria, epistaxis, parenthesis, shortness of breath, constitutional symptoms
or any change in performance status.
Affected patients present with constitutional symptoms
, which progress to severe mental deterioration and movement disorders.
In the week before admission, he had constitutional symptoms
of malaise and vague fevers with anorexia, nausea, and vomiting, and, lately, oliguria.
It is characterized by varying degrees of bone marrow failure, splenic enlargement and debilitating constitutional symptoms
resulting in a significant loss in quality of life and reduced life-span.
Preliminary clinical activity observed in most subjects, including: - Reduction in spleen size of 33 to 100% in five of six patients evaluated - Reduction in erythropoietin-independent colony formation of up to 39% and up to 100% in two patients evaluated -- Relief of constitutional symptoms
, including pruritus, fatigue, back pain and abdominal fullness -- Reduction in the number of cells with the JAK2 V617F mutation (allele burden) -- Correlation between XL019 exposure and decreases in phosphorylation of STAT, a marker for JAK activity.
Inflammatory pseudotumors have been reported to cause chronic cough (as a result of endobronchial growth), (2) dry cough, fever, pleuritic pain, (8) right upper quadrant or epigastric pain, (1) and several constitutional symptoms
, (1-5) such as malaise, weight loss, fatigue, and syncope.
Further dose escalation (up to and including 1,100 mg) has been possible using premedication with a steroid and ibuprofen that reduce constitutional symptoms