contiguous gene syndrome


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contiguous gene syndrome

[kən¦tig·yə·wəs ′jēn ′sin′drōm]
(genetics)
A characteristic complex phenotype produced by deletion of a short chromosome segment, resulting from haplo-insufficiency of several genes in the deleted segment.
References in periodicals archive ?
Second, patients with Greig cephalopolysyndactyly contiguous gene syndrome (GCPS-CGS) have substantial phenotypic overlap with acrocallosal syndrome (13).
23) Interestingly, the genes TSC2 and PKD1 that cause these 2 diseases lie immediately adjacent to each other on chromosome arm 16p136 and a contiguous gene syndrome has been described.
Deletion of the TSC2 and PKD1 genes associated with severe infantile polycystic kidney disease--a contiguous gene syndrome.