corticosterone


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corticosterone

(kôr'təkōstĕr`ōn), steroid hormonehormone,
secretory substance carried from one gland or organ of the body via the bloodstream to more or less specific tissues, where it exerts some influence upon the metabolism of the target tissue.
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 secreted by the outer layer, or cortex, of the adrenal glandadrenal gland
or suprarenal gland
, endocrine gland (see endocrine system) about 2 in. (5.1 cm) long situated atop each kidney. The outer yellowish layer (cortex) of the adrenal gland secretes about 30 steroid hormones, the most important of which are aldosterone and
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. Classed as a glucocorticoid, corticosterone helps regulate the conversion of amino acids into carbohydrates and glycogen by the liver, and helps stimulate glycogen formation in the tissues. Corticosterone is similar in structure, although somewhat less potent, than the other glucocorticoids cortisolcortisol
or hydrocortisone,
steroid hormone that in humans is the major circulating hormone of the cortex, or outer layer, of the adrenal gland. Like cortisone, cortisol is classed as a glucocorticoid; it stimulates liver glycogen formation while it decreases the rate
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 and cortisonecortisone
, steroid hormone whose main physiological effect is on carbohydrate metabolism. It is synthesized from cholesterol in the outer layer, or cortex, of the adrenal gland under the stimulation of adrenocorticotropic hormone (ACTH).
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. It is produced in response to stimulation by the pituitary substance adrenocorticotropic hormoneadrenocorticotropic hormone
, polypeptide hormone secreted by the anterior pituitary gland. Its chief function is to stimulate the cortex of the adrenal gland to secrete adrenocortical steroids, chief among them cortisone.
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 (ACTH). In some species, but not in humans, corticosterone is the predominant glucocorticoid secreted by the adrenal. It is a precursor in the synthesis of aldosteronealdosterone
, steroid secreted by the cortex of the adrenal gland. It is the most potent hormone regulating the body's electrolyte balance. Aldosterone acts directly on the kidney to decrease the rate of sodium-ion excretion (with accompanying retention of water), and to
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, another adrenal cortical steroid.

corticosterone

[‚kȯrd·ə′käs·tə‚rōn]
(biochemistry)
C21H30O4 A steroid hormone produced by the adrenal cortex of vertebrates that stimulates carbohydrate synthesis and protein breakdown and is antagonistic to the action of insulin.
References in periodicals archive ?
Birds with a low level of corticosterone response can achieve better productivity results, as they exhibit an earlier onset of maturation [23,24].
Radioimmunoassay--We determined corticosterone concentrations using radioimmunoassay (ImmuChem[TM] Double Anti-body RIA kit, MP Biomedicals, Orangeburg, New York), following the manufacturer's instructions, with the exception of halving the amounts of reagents used per sample.
The serum corticosterone level was measured using a corticosterone ELISA kit (Nanjing Jiancheng Bioengineering Institute, Jiangsu, China) according to the manufacturer's instructions.
This is suggested by the reductions of corticosterone and adrenocorticotropic hormone, as well as changes in intestinal permeability (ability to hold intestinal contents in place and not have them leak into the bloodstream).
05) for corticosterone, cortisol, progesterone, 21-deoxycortisol, cortisone, DHEA, and DHEA-S after correction for any confounding influence of cosyntropin stimulation.
With this serum corticosterone level was measured in different groups of rats.
Specifically, studies have demonstrated that both stress and the administration of exogenous corticosterone increase microglial activation, reactivity, and proliferation [14, 16, 20].
In addition, we demonstrated that aged male rats exposed to noise stress exhibited higher corticosterone and ACTH levels than the nonstressed rats.
The ACTH concentrations were measured using the adrenocorticotropic hormone ELISA kits (Nanjing Jiancheng Bioengineering Institute, China), and the CORT concentrations were measured using a corticosterone ELISA kits (Nanjingjiancheng Bioengineering Institute, China), following the manufacturer's instruction.
Keywords: Cholesterol lipid profile metabolic syndrome corticosterone nicotine mice.
The young and elderly groups were then separated further according to whether the rats had naturally high or naturally low levels of corticosterone -- the hormone comparable to cortisol in humans.
The study found that aged rats with high levels of the stress hormone corticosterone showed structural changes in the brain and short-term memory deficits.

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