corticosterone


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corticosterone

(kôr'təkōstĕr`ōn), steroid hormonehormone,
secretory substance carried from one gland or organ of the body via the bloodstream to more or less specific tissues, where it exerts some influence upon the metabolism of the target tissue.
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 secreted by the outer layer, or cortex, of the adrenal glandadrenal gland
or suprarenal gland
, endocrine gland (see endocrine system) about 2 in. (5.1 cm) long situated atop each kidney. The outer yellowish layer (cortex) of the adrenal gland secretes about 30 steroid hormones, the most important of which are aldosterone and
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. Classed as a glucocorticoid, corticosterone helps regulate the conversion of amino acids into carbohydrates and glycogen by the liver, and helps stimulate glycogen formation in the tissues. Corticosterone is similar in structure, although somewhat less potent, than the other glucocorticoids cortisolcortisol
or hydrocortisone,
steroid hormone that in humans is the major circulating hormone of the cortex, or outer layer, of the adrenal gland. Like cortisone, cortisol is classed as a glucocorticoid; it stimulates liver glycogen formation while it decreases the rate
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 and cortisonecortisone
, steroid hormone whose main physiological effect is on carbohydrate metabolism. It is synthesized from cholesterol in the outer layer, or cortex, of the adrenal gland under the stimulation of adrenocorticotropic hormone (ACTH).
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. It is produced in response to stimulation by the pituitary substance adrenocorticotropic hormoneadrenocorticotropic hormone
, polypeptide hormone secreted by the anterior pituitary gland. Its chief function is to stimulate the cortex of the adrenal gland to secrete adrenocortical steroids, chief among them cortisone.
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 (ACTH). In some species, but not in humans, corticosterone is the predominant glucocorticoid secreted by the adrenal. It is a precursor in the synthesis of aldosteronealdosterone
, steroid secreted by the cortex of the adrenal gland. It is the most potent hormone regulating the body's electrolyte balance. Aldosterone acts directly on the kidney to decrease the rate of sodium-ion excretion (with accompanying retention of water), and to
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, another adrenal cortical steroid.

corticosterone

[‚kȯrd·ə′käs·tə‚rōn]
(biochemistry)
C21H30O4 A steroid hormone produced by the adrenal cortex of vertebrates that stimulates carbohydrate synthesis and protein breakdown and is antagonistic to the action of insulin.
References in periodicals archive ?
In laying hens, corticosterone causes increased feed intake, reduced weight gain, elevated corticosterone concentrations and heterophil/lymphocyte ratios, higher feather picking, longer tonic immobility, and reduced immune functions (El-lethey et al.
The separated plasma was subsequently stored at -20[degrees]C for determination of corticotrophin-releasing factor (CRF) levels using rat specific ELISA kit obtained from Hoelzel Diagnostics GmbH (Cologne, Germany) and corticosterone levels using rat specific ELISA kit obtained from Assaypro (St.
Individual differences in stress-induced dopamine release in the nucleus accumbens are influenced by corticosterone.
Because exposure to UVR lowers plasma corticosterone concentrations in starlings, (5) we hypothesized that plasma corticosterone levels might also decrease in budgerigars exposed to UVR in our study.
Serum leptin and corticosterone levels after exposure to noise stress in rats.
We think increased boldness and lower corticosterone evolved in concert during colonization, which points to the hypothalamic-pituitary-adrenal axis as a critical integrating hormonal mechanism associated with adapting to urban life," Atwell surmises.
Drugs of abuse also may produce an initial corticosterone response via brainstem PVN-projecting pathways.
Mench JA Research note: Feed restriction in broiler breeders causes a persistent elevation in corticosterone secretion that is modulated by dietary tryptophan.
A coherent pattern among social behavior, blood pressure, corticosterone, and catecholamine measures in individual male rats.
Levels of interleukin (IL)-6, interleukin (IL)-10 and tumour necrosis factor (TNF)-a were analysed in MEAT and RPAT, and leptin, adiponectin, glucose, corticosterone and lipid profile levels were analysed in serum.
Levels of corticosterone (CORT), the major glucocorticoid in reptiles, increase during stress.
After three weeks, the dieting mice had lost 10-15 per cent of their body weight but they also showed increased levels of the stress hormone corticosterone.

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