Weinstock (2008) explored the effect of stress-induced levels of cortisol and corticotrophin
releasing hormone in pregnancy.
They were found to have higher levels of corticotrophin
and cortisol than did normal controls, indicating that they have an overactive hypothalamic-pituitary adrenal (HPA) axis (20).
The effect of smoking on the time course release of catecholamines, corticotrophin
releasing hormone (CRH), adrenocorticotrophin hormone (ACTH), and cortisol in pregnancy.
Examples: Erythropoietin (EPO), growth hormones and corticotrophin
In addition, NA stimulation is associated with the lightening of types of sleep other than REM and increased levels of corticotrophin
releasing factor (CRF).
Early separation from the mother increases corticotrophin
in the amygdala.
In a study of patients with relative adrenal insufficiency--identified by a corticotrophin
stimulation test on admission--those treated with steroids had lower 28-day mortality than did those randomized to receive placebo in addition to standard therapy.
Neurogen Corporation (Branford, CT; 203-315-4615), a leading small molecule drug discovery and development company, and Aventis Pharma (Bridgewater, NJ; 908-231-4659), jointly announced an exclusive worldwide collaboration to develop new drugs for treatment of depression, anxiety, and other stress-related disorders based on Neurogen's innovative portfolio of pre-clinical corticotrophin
releasing factor (CRF1) antagonist compounds.
The 5 loci are linked to functional genes (opiod binding and cell adhesion molecule, corticotrophin
releasing factor, interphotoreceptor retinal binding protein, kappa-casein, insulin-like growth factor-1) in cattle.
SPRED2 was identified as a negative regulator of the Hypothalamic-Pituitary-Adrenal Axis, SPRED2 deficiency leads to an increased MAPK signaling, which results in an augmented its secretagogue corticotrophin
releasing hormone (CRH) promoter activity, the subsequent CRH overproduction causes an upregulation of downstream hypothalamic-pituitary-adrenal (HPA) hormone secretion (Ullrich et al.
Acthar Gel (repository corticotrophin
Other targets for new treatments are receptors for stress-related neuropeptides, including corticotrophin
releasing factor (CRF), neuropeptide Y (NPY), substance P nociceptin (George et al.