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corticotropin

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corticotropin (kôr'təkōtrōp`ən): see adrenocorticotropic hormone adrenocorticotropic hormone , polypeptide hormone secreted by the anterior pituitary gland. Its chief function is to stimulate the cortex of the adrenal gland to secrete adrenocortical steroids, chief among them cortisone.
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corticotropin [‚kȯrd·ə‚kō′trō·pən]
(biochemistry)
A hormonal preparation having adrenocorticotropic activity, derived from the adenohypophysis of certain domesticated animals.


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The Salk Institute for Biological Studies (La Jolla, CA) has patented a G-protein-coupled receptor proteins (CRF-R) characterized by having sufficient binding affinity for corticotropin releasing factor (CRF) such that concentrations of 10 nM of CRF occupy 50% of the binding sites of said receptor protein.
Under stress, fish release corticotropin-releasing hormone (CRH), which triggers the pituitary gland to produce more corticotropin.
 
 
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