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coumarin

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coumarin [′kü·mə·rən]
(organic chemistry)
C9H6O2The anhydride ofo-coumaric acid; a toxic, white, crystalline lactone found in many plants and made synthetically; used in making perfume and soap. Also known as 1,2-benzopyrone.


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The ability of Cd to induce the murine CYP2A5, which is an ortholog of human cytochrome P450 2A6 (CYP2A6), is consistent with results obtained from a study in healthy human subjects, which fotmda positive correlation between Cd burden and accelerated rate of hepatic coumarin metabolism known to be mediated exdusively by CYP2A6 (Satarug et al.
Another study examined coumarin 7-hydroxylation (the enzymatic conversion of plant substances into products that are soluble and can be excreted by the body) in subjects consuming a raw foods vegan diet matched with omnivorous controls, and concluded that plant substances had little effect on coumarin hydroxylase activity in subjects consuming a raw foods diet.
The Food and Drug Administration prohibits the use of coumarin in food because animal tests show it damages the liver and other organs when ingested.
 
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