covalence

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Related to covalently: covalently closed circular DNA

covalency

(US), covalence Chemistry
1. the formation and nature of covalent bonds
2. the number of covalent bonds that a particular atom can make with other atoms in forming a molecule

covalence

[kō′vā·ləns]
(chemistry)
The number of covalent bonds which an atom can form.
References in periodicals archive ?
The Exendin-4 analog is covalently bound to recombinant human albumin (Recombumin(R), provided by Novozymes Biopharma).
Preclinical studies into AFP-464's mechanism of action have shown that AFP-464 induces CYP1A1/1A2 and CYP1B1 protein expression and is converted to metabolites that are covalently bound to DNA, resulting in phosphorylation of p53 with induction of the p53 downstream target p21(Waf1/Cip1) and apoptosis.
He also explained how electrons transfer between species covalently linked by bridging molecules.
Biochemical engineers at the Massachusetts Institute of Technology is Cambridge have covalently bonded microscopic plastic beads to enzymes derived from microbes.
The data showed that AVL-181 bonds selectively, covalently and irreversibly to HCV protease (also known as "NS3/4A"), thus silencing a key protein necessary for successful viral replication resulting in a prolonged duration of action.
Columbia University in the City of New York (New York, NY) has patented synthetic receptors which comprise a polyfunctional organic template covalently linked to two or more oligomers which may independently be the same or different and may independently be straight chain, cyclic or branched.
The mechanism in which this is achieved is believed to be the de-silencing of ER expression by the histone deacetylase inhibitor, followed by CYP1A1 induction and subsequent AFP metabolism into active species that covalently bind to DNA in these cancer cells and cause specific cell death.
The HaloTag technology is based on a unique protein tag which has been engineered from a bacterial dehalogenase to covalently attach to a set of synthetic ligands, such as fluorescent dyes, for cellular imaging applications or to resin and magnetic beads for protein interaction analysis applications.
The equation indicates that the shorter the distance between the atoms and the more equally, or covalently, the atoms share their bonding, or outermost, electrons, the harder the solid.
The assay utilizes monoclonal antibodies or antigen affinity purified polyclonal antibodies covalently coupled to latex beads.
SCHOTT Type I plusA features a coating on the inside that is covalently bonded with the glass matrix and drastically reduces interactions between the glass surface and the respective medication.
The researchers assembled one of the system's two reactants, pentafluorophenyl ester, by covalently bonding it to one arm of a U-shaped molecular frame (Fig.