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C4H9O2N3α-Methylguanidine-acetic acid; a compound present in vertebrate muscle tissue, principally as phosphocreatine.



N-methylguanidoacetic acid. Molecular weight, 131.14; melting point, 315°C (with dissociation):

Creatine is soluble in hot water, slightly soluble in alcohol, and insoluble in ether. The interaction of mineral acids and creatine produces the lactam creatinine. This reaction is the basis of one of the methods used to determine creatine content. Creatine dissociates into urea and methylglycine in an alkaline medium.

Creatine was discovered in 1835 by the French scientist M. Chevreul in extracts from skeletal muscles. It is found in the muscle tissue of all vertebrates (approximately 0.5 percent of the muscle weight) in the form of the unstable creatinephosphoric acid, which takes part in supplying the energy required for muscle contraction. Smaller quantities are present in nerve tissue, blood, liver, and kidneys. Creatine biosynthesis in an organism is achieved in the kidneys from the amino acids glycine and arginine, forming glycocyamine. The glycocyamine undergoes subsequent methylation in the liver in the presence of the amino acid methionine to yield creatine.


References in periodicals archive ?
This result may be explained by the fact that half life of creatin kinase is short [1].
The news follows SUPER SPORT'S exclusive revelation that Arsenal boss Arsene Wenger encourages Gunners' players to take Creatin, the protein powder pioneered in athletics.
2003), it was determined that there is no effect on glucose, urea, creatin, cholesterol, trigliceride, SGOT, and SGPT.
mg/dl) 3,72 [+ ó -] 0,89 (b) 3,44-4,01 magnesio (mg/dl) 2,76 [+ ó -] 0,25 (a) 2,67-2,85 cobre (pg/dl) 129 [+ ó -] 33 (b) 114-145 ALP (UI/l) 56 [+ ó -] 19 (a) 50-62 ALT (UI/l) 14 [+ ó -] 5 (a) 13-16 AST (UI/l) 66 [+ ó -] 20 (b) 60-73 GGT (UI/l) 11 [+ ó -] 5 (a) 8-14 CPK (UI/l) 108 [+ ó -] 68 (a) 83-132 LDH (UI/l) 277 [+ ó -] 156 (a) 147-407 bCHE (UI/l) 307 [+ ó -] 163 (b) 254-359 RAG: relación albúminas/globulinas; HDL y LDL: lipoproteínas de alta y baja densidad; ALP: fosfatasa alcalina; ALT: alanin aminotrasferasa; AST: aspartato aminotransferasa; GGT: gammaglutamil transferasa; CPK: creatin fosfoquinasa; LDH: lactato deshidrogenasa; bCHE: butiril colinesterasa.
body weight body weight starting at the end of at the end of group body weight wk 1 wk 2 Creatin 132.
Lip Creatin Refill also comes in a trial size that provides more than a dozen uses per shade, according to executives.
Instead of driving into position A, smacking it on to the green and putting once or twice, which was his much-envied hallmark, he found himself saving a score rather than creatin g it.
Gunners' stars take the human growth hormone Creatin every day, under orders from coach Arsene Wenger.
NICKL the list that w this su Martin The I creatin image exodus The Irishman will set about creating a side in his own image this summer and the exodus of full internationals could reach double figures.
The Scots sprinter, who is fighting the results of two positive drugs test, has been singing the praises of Creatin 7000ES.
The players were also given the controversial fitness enhancing Creatin.